Peripheral ApoE4 Leads to Cerebrovascular Dysfunction and Aβ Deposition in Alzheimer's Disease.
作者信息
Sun Rui, Xie Chunming
机构信息
Department of Neurology, School of Medicine, Affiliated Zhongda Hospital, Southeast University, Nanjing, 210009, China.
Institute of Neuropsychiatry, Affiliated Zhongda Hospital, Southeast University, Nanjing, 210009, China.
出版信息
Neurosci Bull. 2023 Aug;39(8):1330-1332. doi: 10.1007/s12264-023-01058-1. Epub 2023 Apr 24.
Abstract
摘要
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Peripheral apoE4 enhances Alzheimer's pathology and impairs cognition by compromising cerebrovascular function.外周型载脂蛋白 E4 通过损害脑血管功能增强阿尔茨海默病病理并损害认知。
Nat Neurosci. 2022 Aug;25(8):1020-1033. doi: 10.1038/s41593-022-01127-0. Epub 2022 Aug 1.
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Blood-Brain Barrier Breakdown: An Emerging Biomarker of Cognitive Impairment in Normal Aging and Dementia.血脑屏障破坏：正常衰老和痴呆中认知障碍的一种新兴生物标志物。
Front Neurosci. 2021 Aug 19;15:688090. doi: 10.3389/fnins.2021.688090. eCollection 2021.
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A randomized, controlled clinical trial of plasma exchange with albumin replacement for Alzheimer's disease: Primary results of the AMBAR Study.一项针对阿尔茨海默病患者采用血浆置换联合白蛋白替代治疗的随机、对照临床试验：AMBAR 研究的主要结果。
Alzheimers Dement. 2020 Oct;16(10):1412-1425. doi: 10.1002/alz.12137. Epub 2020 Jul 27.
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Microbial involvement in Alzheimer disease development and progression.微生物与阿尔茨海默病发生发展的关系
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APOE4 leads to blood-brain barrier dysfunction predicting cognitive decline.载脂蛋白 E4 导致血脑屏障功能障碍，预测认知能力下降。
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