通过NADPH和还原型谷胱甘肽（GSH）使粗面内质网的核糖体脱离。

Detachment of ribosomes of rough endoplasmic reticulum by NADPH and reduced glutathione (GSH).

作者信息

Akintonwa D A

出版信息

Ecotoxicol Environ Saf. 1986 Apr;11(2):153-7. doi: 10.1016/0147-6513(86)90059-x.

Abstract

NADPH, an endogenous, naturally occurring compound was found to be positive in the stripping of ribosomes from rough endoplasmic reticulum (RER) test (degranulation) for carcinogens using the hepatocellular postmitochondrial (PMS) system. However, glutathione (GSH) another naturally occurring compound was negative in the hepatocellular PMS system in contrast to GSH which was previously reported as being positive in the mutagenicity test using kidney PMS but negative using liver PMS. Akintonwa has classified degranulation into three types, viz, DIA, DIB, and DII (D.A.A. Akintonwa, Ecotoxicol. Environ. Saf. 9, 53-63 (1985]. Most carcinogens fall into DIA and DIB types. NADPH was of DIA type in the mouse and of DII in the female rat PMS systems. NADPH was consistently negative in the male rat PMS system.

摘要

NADPH是一种内源性的天然存在的化合物，在使用肝细胞线粒体后（PMS）系统进行的致癌物粗面内质网（RER）核糖体剥离试验（脱粒）中呈阳性。然而，另一种天然存在的化合物谷胱甘肽（GSH）在肝细胞PMS系统中呈阴性，这与之前报道的GSH在使用肾脏PMS的致突变性试验中呈阳性但在使用肝脏PMS时呈阴性形成对比。阿金通瓦将脱粒分为三种类型，即DIA、DIB和DII（D.A.A.阿金通瓦，《生态毒理学与环境安全》9，53 - 63（1985年））。大多数致癌物属于DIA和DIB类型。NADPH在小鼠PMS系统中属于DIA型，在雌性大鼠PMS系统中属于DII型。NADPH在雄性大鼠PMS系统中始终呈阴性。