Inayat Samsoon, McAllister Brendan B, Whishaw Ian Q, Mohajerani Majid H
Canadian Centre for Behavioural Neuroscience, University of Lethbridge, Lethbridge, AB, Canada.
iScience. 2023 Mar 21;26(4):106481. doi: 10.1016/j.isci.2023.106481. eCollection 2023 Apr 21.
Hippocampal CA1 neurons respond to sensory stimuli during enforced immobility, movement, and their transitions in a new conveyor belt task. Head-fixed mice were exposed to light flashes or air streams while at rest, spontaneously moving, or running a fixed distance. Two-photon calcium imaging of CA1 neurons revealed that 62% of 3341 imaged cells were active during one or more of 20 sensorimotor events. Of these active cells, 17% were active for any given sensorimotor event, with a higher proportion during locomotion. The study found two types of cells: Conjunctive cells that were active across multiple events, and complementary cells that were active only during individual events, encoding novel sensorimotor events or their delayed repetitions. The configuration of these cells across changing sensorimotor events may signify the role of hippocampus in functional networks integrating sensory information with ongoing movement making it suitable for movement guidance.
在一项新的传送带任务中，海马体CA1神经元在强制静止、运动及其转换过程中对感觉刺激作出反应。将头部固定的小鼠在静止、自发运动或跑固定距离时暴露于闪光或气流中。对CA1神经元进行的双光子钙成像显示，在3341个成像细胞中，62%在20个感觉运动事件中的一个或多个期间处于活跃状态。在这些活跃细胞中，17%在任何给定的感觉运动事件中都活跃，在运动期间比例更高。该研究发现了两种类型的细胞：在多个事件中都活跃的联合细胞，以及仅在个别事件期间活跃的互补细胞，它们编码新的感觉运动事件或其延迟重复。这些细胞在不断变化的感觉运动事件中的配置可能表明海马体在将感觉信息与正在进行的运动整合的功能网络中的作用，使其适合于运动引导。
