Steardo L, Di Stasio E, Bonuso S, Maj M
Eur J Clin Pharmacol. 1986;29(6):713-5. doi: 10.1007/BF00615964.
The effect of the ergot derivative bromocriptine (5 mg orally) on blood pressure and plasma catecholamine concentrations was explored in normal volunteers. A significant decrease of plasma noradrenaline was found, while dopamine and adrenaline concentrations did not change significantly. Systolic and diastolic blood pressures were significantly lowered at 150 min after administration. The hypotensive effect of bromocriptine seems to be mediated by a lowered release of noradrenaline from sympathetic nerve endings. It may be hypothesized that the drug stimulates presynaptic dopamine receptors located on postganglionic sympathetic nerves, thus inhibiting noradrenaline discharge.
在正常志愿者中探究了麦角衍生物溴隐亭（口服5毫克）对血压和血浆儿茶酚胺浓度的影响。发现血浆去甲肾上腺素显著降低，而多巴胺和肾上腺素浓度无显著变化。给药后150分钟时收缩压和舒张压显著降低。溴隐亭的降压作用似乎是由交感神经末梢去甲肾上腺素释放减少介导的。可以推测，该药物刺激位于节后交感神经上的突触前多巴胺受体，从而抑制去甲肾上腺素的释放。
