Matsui K
Jikken Dobutsu. 1986 Jan;35(1):29-33. doi: 10.1538/expanim1978.35.1_29.
Changes of cerebellar weight, spontaneous movement and ataxia with aging were investigated in Weaver and cytosine arabinoside-injected mice (Ara-C). In addition, changes of cerebellar NA and MHPG concentrations in both mice were measured by high performance liquid chromatography. Cerebellar weight increased with aging in both mice. Spontaneous movements in Weaver mice were not significantly changed, but Ara-C mice showed a decreasing tendency with aging. Ataxic gait improved with aging in Weaver mice, but not in Ara-C mice. With aging, cerebellar NA and MHPG concentrations were decreased in controls, but not in Ara-C mice. In Weaver mice, cerebellar MHPG concentration was decreased. These results suggest that NA turnover in ataxic mice is different from that in controls, but is not correlated closely with ataxia.
研究了韦弗（Weaver）小鼠和注射阿糖胞苷（Ara-C）的小鼠随着衰老小脑重量、自发运动和共济失调的变化。此外，通过高效液相色谱法测量了两种小鼠小脑去甲肾上腺素（NA）和3-甲氧基-4-羟基苯乙二醇（MHPG）的浓度变化。两种小鼠的小脑重量均随衰老而增加。韦弗小鼠的自发运动没有显著变化，但阿糖胞苷小鼠随着衰老呈现下降趋势。韦弗小鼠的共济失调步态随衰老而改善，但阿糖胞苷小鼠则不然。随着衰老，对照组小鼠的小脑NA和MHPG浓度降低，但阿糖胞苷小鼠没有。在韦弗小鼠中，小脑MHPG浓度降低。这些结果表明，共济失调小鼠的NA周转率与对照组不同，但与共济失调没有密切相关性。
