Matsui K, Masui A, Kato N, Adachi K
National Institute of Neuroscience, NCNP, Tokyo, Japan.
Life Sci. 1993;53(4):333-40. doi: 10.1016/0024-3205(93)90752-o.
Changes in immunoreactive somatostatin (SOM) and cholecystokinin (CCK-8) levels in the cerebellum and cerebrum were investigated in three types of genetically-determined ataxic mutant mice: rolling mouse Nagoya (RMN), weaver, and Purkinje cell degeneration (PCD) mice. The cerebellar pathology in each of these types differs. The concentration of both SOM and CCK-8 (ng/mg weight) was significantly higher in the cerebellum and the cerebrum of the three types of ataxic mutant mice than in these regions in the respective controls. SOM and CCK-8 content (ng/organ) was significantly higher in PCD and RMN than in controls but this was not in the weaver mice. The possible involvement of both peptides in manifestations of ataxia is discussed.
在三种基因决定的共济失调突变小鼠中，即滚动小鼠名古屋（RMN）、韦弗小鼠和浦肯野细胞变性（PCD）小鼠，研究了小脑和大脑中免疫反应性生长抑素（SOM）和胆囊收缩素（CCK-8）水平的变化。这些类型的小鼠各自的小脑病理学有所不同。三种共济失调突变小鼠的小脑和大脑中SOM和CCK-8的浓度（纳克/毫克体重）均显著高于各自对照组的相应区域。PCD小鼠和RMN小鼠中SOM和CCK-8的含量（纳克/器官）显著高于对照组，但韦弗小鼠并非如此。文中讨论了这两种肽可能与共济失调表现的关联。
