接受外照射放疗与高剂量率近距离放疗的前列腺癌患者的情绪困扰发生率及危险因素。

Prevalence and Risk Factors of Emotional Distress in Patients With Prostate Cancer Assigned to External-beam Radiotherapy With or Without High-dose Rate Brachytherapy.

机构信息

Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.

Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, U.S.A.

出版信息

Anticancer Res. 2023 May;43(5):2103-2109. doi: 10.21873/anticanres.16371.

DOI:10.21873/anticanres.16371

PMID:37097699

Abstract

BACKGROUND/AIM: Upcoming radiotherapy for prostate cancer may lead to emotional distress. This study aimed to identify the prevalence and risk factors in a retrospective cohort of 102 patients.

PATIENTS AND METHODS

Thirteen characteristics were evaluated for six emotional problems. To account for multiple comparisons, Bonferroni correction was used; p-values <0.0038 were significant (alpha level <0.05).

RESULTS

Prevalence of worry, fears, sadness, depression, nervousness, and loss of interest in usual activities was 25%, 27%, 11%, 11%, 18%, and 5%, respectively. A greater number of physical problems was significantly associated with worry (p=0.0037) and fears (p<0.0001) and showed trends regarding sadness (p=0.011) and depression (p=0.011). Trends were also found for associations between younger age and worry (p=0.021), advanced primary tumor stage and fears (p=0.025), patient's history of another malignancy and nervousness (p=0.035), and between external-beam radiotherapy alone and fears (p=0.042) or nervousness (p=0.037).

CONCLUSION

Although the prevalence of emotional distress was comparably low, patients with risk factors may benefit from early psychological support.

摘要

背景/目的：即将进行的前列腺癌放疗可能会导致情绪困扰。本研究旨在回顾性分析 102 例患者，确定其发生率和危险因素。

方法

评估了 13 个特征与 6 种情绪问题的关系。为了校正多重比较，采用 Bonferroni 校正；p 值<0.0038 具有统计学意义（alpha 水平<0.05）。

结果

担忧、恐惧、悲伤、抑郁、紧张和对日常活动失去兴趣的发生率分别为 25%、27%、11%、11%、18%和 5%。更多的身体问题与担忧（p=0.0037）和恐惧（p<0.0001）显著相关，与悲伤（p=0.011）和抑郁（p=0.011）也存在趋势。年轻（p=0.021）、肿瘤分期较晚（p=0.025）、有其他恶性肿瘤病史（p=0.035）、单纯外照射放疗（p=0.042）或紧张（p=0.037）也与这些情绪问题存在相关性。