Department of Radiation Oncology, University of Lübeck, Lübeck, Germany.
Department of Radiation Oncology, Mayo Clinic, Phoenix, AZ, U.S.A.
Anticancer Res. 2023 May;43(5):2103-2109. doi: 10.21873/anticanres.16371.
BACKGROUND/AIM: Upcoming radiotherapy for prostate cancer may lead to emotional distress. This study aimed to identify the prevalence and risk factors in a retrospective cohort of 102 patients.
Thirteen characteristics were evaluated for six emotional problems. To account for multiple comparisons, Bonferroni correction was used; p-values <0.0038 were significant (alpha level <0.05).
Prevalence of worry, fears, sadness, depression, nervousness, and loss of interest in usual activities was 25%, 27%, 11%, 11%, 18%, and 5%, respectively. A greater number of physical problems was significantly associated with worry (p=0.0037) and fears (p<0.0001) and showed trends regarding sadness (p=0.011) and depression (p=0.011). Trends were also found for associations between younger age and worry (p=0.021), advanced primary tumor stage and fears (p=0.025), patient's history of another malignancy and nervousness (p=0.035), and between external-beam radiotherapy alone and fears (p=0.042) or nervousness (p=0.037).
Although the prevalence of emotional distress was comparably low, patients with risk factors may benefit from early psychological support.
背景/目的：即将进行的前列腺癌放疗可能会导致情绪困扰。本研究旨在回顾性分析 102 例患者，确定其发生率和危险因素。
评估了 13 个特征与 6 种情绪问题的关系。为了校正多重比较，采用 Bonferroni 校正；p 值<0.0038 具有统计学意义（alpha 水平<0.05）。
担忧、恐惧、悲伤、抑郁、紧张和对日常活动失去兴趣的发生率分别为 25%、27%、11%、11%、18%和 5%。更多的身体问题与担忧（p=0.0037）和恐惧（p<0.0001）显著相关，与悲伤（p=0.011）和抑郁（p=0.011）也存在趋势。年轻（p=0.021）、肿瘤分期较晚（p=0.025）、有其他恶性肿瘤病史（p=0.035）、单纯外照射放疗（p=0.042）或紧张（p=0.037）也与这些情绪问题存在相关性。
尽管情绪困扰的发生率相对较低，但存在危险因素的患者可能受益于早期心理支持。
