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[小肠黏膜不同氧合方法对葡萄糖和甘氨酸转运动力学特征的影响]

[Effect of various methods of oxygenation of the small intestine mucosa on the kinetic characteristics of glucose and glycine transport].

作者信息

Ekkert L G, Gromova L V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1986 Apr;72(4):431-6.

PMID:3709873
Abstract

Nutrient transport in the small intestine in different conditions of oxygenation of the mucosa in vitro has been studied using original approaches. New experimental data revealed two types of cellular respiration: basolateral and apical ones. Mucosal, serosal and bilateral oxygenations were shown to affect kinetic characteristics (Kt, Vmax) of glucose and glycine active transport in the small intestine. The effect of starvation on the active transport of glucose in the small intestine in different conditions of oxygenation, is discussed. When passing from satiety to starvation state, active accumulation of glucose in the tissue increased during serosal oxygenation and decreased during mucosal and bilateral oxygenation. Characteristic features of functioning of the two types of cellular respiration were investigated in various periods of starvation.

摘要

利用原创方法对体外小肠黏膜在不同氧合条件下的营养物质转运进行了研究。新的实验数据揭示了两种细胞呼吸类型:基底侧呼吸和顶端呼吸。结果表明,黏膜、浆膜和双侧氧合会影响小肠中葡萄糖和甘氨酸主动转运的动力学特征(Kt、Vmax)。讨论了饥饿对不同氧合条件下小肠葡萄糖主动转运的影响。从饱腹状态转变为饥饿状态时,在浆膜氧合期间组织中葡萄糖的主动积累增加,而在黏膜和双侧氧合期间减少。在饥饿的不同阶段研究了两种细胞呼吸类型的功能特征。

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