Zülke Andrea, Luppa Melanie, Köhler Sebastian, Riedel-Heller Steffi G
Institut für Sozialmedizin, Arbeitsmedizin und Public Health (ISAP), Medizinische Fakultät, Universität Leipzig, Philipp-Rosenthal-Str. 55, 04103, Leipzig, Deutschland.
Department of Psychiatry and Neuropsychology and School for Mental Health and Neuroscience (MHeNS), Maastricht University, Maastricht, Niederlande.
Nervenarzt. 2023 May;94(5):384-391. doi: 10.1007/s00115-023-01471-x. Epub 2023 Apr 26.
The scientific state of knowledge on modifiable risk factors for dementia has greatly improved in recent years. The established risk and protective factors include physical and social inactivity, hypertension, diabetes mellitus, excessive alcohol consumption and smoking; however, it is assumed that this knowledge is so far insufficiently disseminated among the general population, indicating untapped potential for primary prevention of dementia.
To assess the state of knowledge on established risk and protective factors for dementia in the general population.
Based on a systematic literature search in the PubMed database, international studies that investigated the knowledge on modifiable risk and/or protective factors for dementia in samples from the general population were identified.
A total of 21 publications were included in the review. The majority of publications (n = 17) collated risk and protective factors using closed questions, while n = 4 studies used open questions. Lifestyle factors, e.g. cognitive, social and physical activity, were most frequently named as protective against dementia. Furthermore, many participants recognized depression as a risk factor for dementia. Knowledge of cardiovascular risk constellations for dementia, such as hypertension, hypercholesterolemia or diabetes mellitus were much less known among the participants. The results indicate that there is a need for a targeted clarification of the role of pre-existing cardiovascular diseases as risk factors for dementia. Studies assessing the state of knowledge on social and environmental risk and protective factors for dementia are currently scarce.
近年来,关于痴呆症可改变风险因素的科学知识状况有了很大改善。已确定的风险和保护因素包括身体和社交活动不足、高血压、糖尿病、过度饮酒和吸烟;然而,据推测,到目前为止,这些知识在普通人群中的传播还不够充分,这表明痴呆症一级预防存在尚未开发的潜力。
评估普通人群对已确定的痴呆症风险和保护因素的认知状况。
基于对PubMed数据库的系统文献检索,确定了在普通人群样本中调查痴呆症可改变风险和/或保护因素知识的国际研究。
该综述共纳入21篇出版物。大多数出版物(n = 17)使用封闭式问题整理风险和保护因素,而n = 4项研究使用开放式问题。生活方式因素,如认知、社交和身体活动,最常被提及为预防痴呆症的因素。此外,许多参与者认识到抑郁症是痴呆症的一个风险因素。参与者对痴呆症的心血管风险组合,如高血压、高胆固醇血症或糖尿病的了解要少得多。结果表明,有必要针对性地阐明既往心血管疾病作为痴呆症风险因素的作用。目前,评估痴呆症社会和环境风险及保护因素知识状况的研究很少。