Department of Family and Preventive Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand.
Nutr Cancer. 2023;75(6):1454-1463. doi: 10.1080/01635581.2023.2205054. Epub 2023 Apr 26.
Diabetes mellitus is widely thought to be a risk factors of cancers, but evidence of the association remains inconclusive, especially in Asian countries where few relevant studies have been conducted. Our study aimed to estimate overall and specific types of cancer risks among diabetes patients in Southern Thailand. Patients diagnosed with diabetes who visited the outpatient clinic of Songklanagarind Hospital during 2004 to 2018 were included. Newly diagnosed cancer patients were identified using the hospital-based cancer registry. Age-standardized incidence ratios (ASRs) and standardized incidence ratios (SIRs) were used to estimate and compare the cancer risks among diabetes patients and the general population in Southern Thailand. Of 29,314 diabetes patients identified during the study period, 1,113 patients had developed cancer. An increased risk for overall cancer was observed in both genders, with SIRs [95% CI] of 2.99 [2.65, 3.39] in men and 3.51 [3.12, 3.96] in women. Increases in the risk of several site-specific cancers including liver cancer, non-melanoma skin cancer, colon cancer and lung cancer in both sexes; prostate cancer, lymphoid leukemia, and multiple myeloma in men; and endometrial, breast, and thyroid cancer in women were observed. Our study found that diabetes generally increased the risk of both overall and site-specific cancers.
糖尿病被广泛认为是癌症的危险因素，但关联的证据仍不确定，特别是在亚洲国家，相关研究较少。我们的研究旨在估计泰国南部糖尿病患者的总体和特定类型癌症风险。该研究纳入了 2004 年至 2018 年期间在宋卡拉林医院门诊就诊的被诊断患有糖尿病的患者。通过医院癌症登记处确定新诊断的癌症患者。使用年龄标准化发病率比（ASR）和标准化发病率比（SIR）来估计和比较泰国南部糖尿病患者和普通人群的癌症风险。在研究期间，共确定了 29314 名糖尿病患者，其中 1113 名患者发生了癌症。在男女两性中均观察到总体癌症风险增加，男性的 SIR [95%CI]为 2.99 [2.65, 3.39]，女性为 3.51 [3.12, 3.96]。在两性中均观察到几种特定部位癌症的风险增加，包括肝癌、非黑色素瘤皮肤癌、结肠癌和肺癌；男性的前列腺癌、淋巴样白血病和多发性骨髓瘤；以及女性的子宫内膜癌、乳腺癌和甲状腺癌。我们的研究发现，糖尿病通常会增加总体和特定部位癌症的风险。
