Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Department of Mathematics and Statistics, Chonnam National University, 77, Yongbong-ro, Buk-gu, Gwangju 61186, Korea; Lishui Second People's Hospital Affiliated to Wenzhou Medical University, Lishui, 323000, China.
Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), Institute of Aging, Key Laboratory of Alzheimer's Disease of Zhejiang Province, Zhejiang Provincial Clinical Research Center for Mental Disorders, The Affiliated Wenzhou Kangning Hospital, School of Mental Health, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China; Alberta Institute, School of Mental Health, Wenzhou Medical University, Wenzhou 325035, China.
Sci Total Environ. 2023 Jul 20;883:163553. doi: 10.1016/j.scitotenv.2023.163553. Epub 2023 Apr 25.
Although air pollutions cause human diseases, no epidemiological study has investigated the effect of exposure to air pollutants on brain diseases in the general population. Our objective was to examine the association between tropospheric airborne pollutants and human health risk and global burden, especially, attributable to indoor formaldehyde (FA) pollution in China. The data of tropospheric pollutants, such as: CO, NO, O, PM2.5 or PM10, SO, and FA in China, 2013-2019, which were derived from the database of satellite remote-sensing, were first calculated and then analyzed them according to satellite cloud pictures. The rate of prevalence, incidence, deaths, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) of the Chinese population was obtained from the Global Burden of Diseases (GBD 2010). A linear regression analysis was used to evaluate the relationship between tropospheric FA concentrations and GBD indexes of human brain diseases, the numbers of fire plot, the average summer temperature, population density and car sales in China from 2013 to 2019. Our results showed that the levels of tropospheric FA could reflect the degree of indoor air FA pollution on a nationwide scale in China; in particular, only tropospheric FA exhibited a positive correlation with the rates of both prevalence and YLDs in brain diseases including: Alzheimer's disease (AD) and brain cancer, but not in Parkinson's disease and depression. In particular, the spatial-temporal changes in tropospheric FA levels were consistent with the geographical distribution of FA exposure-induced AD and brain cancer in both sex old adults with age (60-89). In addition, summer average temperature, car sales and population density were positively correlated with tropospheric FA levels in China, 2013-2019. Hence, mapping of tropospheric pollutants could be used for air quality monitoring and health risk assessment.
尽管空气污染会导致人类疾病，但没有流行病学研究调查过暴露于空气污染物对普通人群中脑部疾病的影响。我们的目的是研究对流层空气污染物与人类健康风险和全球负担的关系，特别是中国室内甲醛（FA）污染造成的风险和负担。我们首先根据卫星云图计算并分析了 2013-2019 年中国对流层污染物（如 CO、NO、O、PM2.5 或 PM10、SO 和 FA）的数据，这些数据来自卫星遥感数据库。从全球疾病负担（GBD 2010）中获得了中国人口的患病率、发病率、死亡率、寿命损失年（YLL）、失能生命年（YLD）和伤残调整生命年（DALY）。我们采用线性回归分析评估了 2013-2019 年中国对流层 FA 浓度与人类脑部疾病 GBD 指标、火灾次数、夏季平均气温、人口密度和汽车销售量之间的关系。结果表明，对流层 FA 水平可以反映全国范围内的室内空气 FA 污染程度；特别是，只有对流层 FA 与包括阿尔茨海默病（AD）和脑癌在内的脑部疾病的患病率和 YLD 率呈正相关，而与帕金森病和抑郁症无关。特别是，对流层 FA 水平的时空变化与 FA 暴露所致 AD 和脑癌在老年（60-89 岁）男女中的地理分布一致。此外，2013-2019 年中国夏季平均气温、汽车销售量和人口密度与对流层 FA 水平呈正相关。因此，对流层污染物的制图可用于空气质量监测和健康风险评估。
