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母亲肠道微生物群对婴儿微生物组和大脑发育的影响。

Impact of the mother's gut microbiota on infant microbiome and brain development.

机构信息

Laboratory of Veterinary Physiology, Department of Veterinary Medicine, Faculty of Agriculture, Tokyo University of Agriculture and Technology, 3-5-8 Saiwai Cho, Fuchu-shi, Tokyo 183-8509, Japan; Department of Animal Hygiene, Behavior and Management, Faculty of Veterinary Medicine, Benha University, Moshtohor, Toukh, Elqaliobiya 13736, Egypt.

Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, Cairo 11829, Egypt; Biochemistry and Molecular Biology Department, Faculty of Pharmacy (Boys), Al-Azhar University, Nasr City, Cairo 11231, Egypt.

出版信息

Neurosci Biobehav Rev. 2023 Jul;150:105195. doi: 10.1016/j.neubiorev.2023.105195. Epub 2023 Apr 24.

Abstract

The link between the gut microbiome and health has recently garnered considerable interest in its employment for medicinal purposes. Since the early microbiota exhibits more flexibility compared to that of adults, there is a considerable possibility that altering it will have significant consequences on human development. Like genetics, the human microbiota can be passed from mother to child. This provides information on early microbiota acquisition, future development, and prospective chances for intervention. The succession and acquisition of early-life microbiota, modifications of the maternal microbiota during pregnancy, delivery, and infancy, and new efforts to understand maternal-infant microbiota transmission are discussed in this article. We also examine the shaping of mother-to-infant microbial transmission, and we then explore possible paths for future research to advance our knowledge in this area.

摘要

肠道微生物组与健康之间的联系最近引起了人们的极大关注,因为它可以用于医学目的。由于早期微生物组比成人的微生物组更具灵活性,因此很有可能改变它会对人类发育产生重大影响。与遗传因素一样,人类微生物组可以从母亲传给孩子。这提供了有关早期微生物组获取、未来发展和潜在干预机会的信息。本文讨论了早期生命微生物组的演替和获取、妊娠、分娩和婴儿期母体微生物组的改变,以及新的努力来理解母婴微生物组传播。我们还研究了母子间微生物传播的形成方式,然后探讨了未来研究的可能途径,以增进我们在这一领域的知识。

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