Beijing Institutes of Life Science, Chinese Academy of Sciences, Beijing, China.
University of Chinese Academy of Sciences, Beijing, China.
Gut. 2023 Apr;72(4):772-786. doi: 10.1136/gutjnl-2022-328970. Epub 2023 Jan 31.
The microbiome has been proven to be associated with many diseases and has been used as a biomarker and target in disease prevention and intervention. Currently, the vital role of the microbiome in pregnant women and newborns is increasingly emphasised. In this review, we discuss the interplay of the microbiome and the corresponding immune mechanism between mothers and their offspring during the perinatal period. We aim to present a comprehensive picture of microbial transmission and potential immune imprinting before and after delivery. In addition, we discuss the possibility of in utero microbial colonisation during pregnancy, which has been highly debated in recent studies, and highlight the importance of the microbiome in infant development during the first 3 years of life. This holistic view of the role of the microbial interplay between mothers and infants will refine our current understanding of pregnancy complications as well as diseases in early life and will greatly facilitate the microbiome-based prenatal diagnosis and treatment of mother-infant-related diseases.
微生物组已被证明与许多疾病有关，并已被用作疾病预防和干预的生物标志物和靶点。目前，微生物组在孕妇和新生儿中的重要作用越来越受到重视。在这篇综述中，我们讨论了围产期母亲及其后代之间微生物组和相应免疫机制的相互作用。我们旨在全面描述分娩前后微生物的传播和潜在的免疫印记。此外，我们还讨论了怀孕期间胎儿内微生物定植的可能性，这在最近的研究中备受争议，并强调了微生物组在婴儿生命的头 3 年中发育的重要性。这种对母亲和婴儿之间微生物相互作用的整体作用的看法将完善我们对妊娠并发症以及婴儿早期疾病的现有认识，并极大地促进基于微生物组的母婴相关疾病的产前诊断和治疗。
