Hughes Alec, Khan Dure S, Alkins Ryan
School of Medicine, Faculty of Health Sciences, Queen's University, Kingston, ON, Canada.
Centre for Neuroscience Studies, Queen's University, Kingston, ON, Canada.
Ultrasound Med Biol. 2023 Jul;49(7):1479-1490. doi: 10.1016/j.ultrasmedbio.2023.02.017. Epub 2023 Apr 24.
With an ever-growing list of neurological applications of focused ultrasound (FUS), there has been a consequent increase in the variety of systems for delivering ultrasound energy to the brain. Specifically, recent successful pilot clinical trials of blood-brain barrier (BBB) opening with FUS have generated substantial interest in the future applications of this relatively novel therapy, with divergent, purpose-built technologies emerging. With many of these technologies at various stages of pre-clinical and clinical investigation, this article seeks to provide an overview and analysis of the numerous medical devices in active use and under development for FUS-mediated BBB opening.
随着聚焦超声（FUS）在神经学领域的应用不断增加，将超声能量传递到大脑的系统种类也相应增加。具体而言，最近关于使用FUS打开血脑屏障（BBB）的成功试点临床试验引发了人们对这种相对新颖疗法未来应用的浓厚兴趣，各种专门设计的技术也应运而生。由于这些技术中的许多正处于临床前和临床研究的不同阶段，本文旨在对目前正在积极使用和开发的用于FUS介导的BBB开放的众多医疗设备进行概述和分析。
