Division of Acute Care Surgery, Department of Surgery, Korea University Anam Hospital, Korea University Medical Center, Goryeodae-ro 73, Seongbuk-gu, Seoul, 02841, Republic of Korea.
Sci Rep. 2023 Apr 26;13(1):6845. doi: 10.1038/s41598-023-33539-8.
Invasive arterial line insertion is a common procedure in the intensive care unit ICU; however, it can cause unnecessary blood loss while procuring blood for laboratory tests. To reduce blood loss resulting from flushing out the arterial line dead space, we developed a new blood-preserving arterial line system: Hematic Auto-Management & Extraction for arterial Line (HAMEL, MUNE Corp.). Five male three-way crossbred pigs were used to evaluate the necessary amount of blood to be withdrawn before sampling to produce accurate results. We then tested whether the traditional sampling method and the HAMEL system showed non-inferior results for blood tests. Blood gas (CG4 + cartridge) and chemistry (CHEM8 + cartridge) analyses were used for comparison. The total unnecessary blood loss in the traditional sampling group was 5 mL/sample. For HAMEL, withdrawing 3 mL of blood before sampling yielded hematocrit and hemoglobin results within 90% confidence interval of traditional sampling group. Most intra-class correlation coefficients between the traditional sampling and HAMEL system groups were > 0.90. When compared to the traditional sampling method, withdrawal of 3 mL with HAMEL was sufficient before blood sampling. Utilization of the HAMEL system was not inferior to the traditional hand-sampling method. In addition, no unnecessary blood loss occurred in the HAMEL system.
经皮动脉置管术是重症监护病房(ICU)中的常见操作,但在为实验室检测采集血液时可能会导致不必要的失血。为了减少因冲洗动脉置管死腔而导致的失血,我们开发了一种新的保留血液的动脉置管系统:Hematic Auto-Management & Extraction for arterial Line(HAMEL,MUNE 公司)。我们使用 5 头雄性杂交猪来评估在采样前需要抽取多少血液以获得准确的结果。然后,我们测试了传统的采样方法和 HAMEL 系统是否在血液检测方面具有非劣效性。我们比较了血气(CG4 + 试剂盒)和化学分析(CHEM8 + 试剂盒)。传统采样组的总失血量为 5 毫升/样本。对于 HAMEL,在采样前抽取 3 毫升血液可使血细胞比容和血红蛋白结果在传统采样组 90%置信区间内。传统采样组和 HAMEL 系统组之间的大多数组内相关系数均大于 0.90。与传统的采样方法相比,使用 HAMEL 系统在采样前抽取 3 毫升血液即可满足要求。HAMEL 系统的使用并不逊于传统的手工采样方法。此外,HAMEL 系统不会发生不必要的失血。