多组学时代的颅内出血管理
Intracranial hemorrhage management in the multi-omics era.
作者信息
Feng Xianjing, Li Xi, Feng Jie, Xia Jian
机构信息
Department of Neurology, Xiangya Hospital, Central South University, Changsha, China.
Clinical Research Center for Cerebrovascular Disease of Hunan Province, Central South University, Changsha, China.
出版信息
Heliyon. 2023 Mar 22;9(3):e14749. doi: 10.1016/j.heliyon.2023.e14749. eCollection 2023 Mar.
Intracranial hemorrhage (ICH) is a devastating disorder. Neuroprotective strategies that prevent tissue injury and improve functional outcomes have been identified in multiple animal models of ICH. However, these potential interventions in clinical trials produced generally disappointing results. With progress in omics, studies of omics data, including genomics, transcriptomics, epigenetics, proteomics, metabolomics, and the gut microbiome, may help promote precision medicine. In this review, we focused on introducing the applications of all omics in ICH and shed light on all of the considerable advantages to systematically analyze the necessity and importance of multiple omics technology in ICH.
颅内出血（ICH）是一种极具破坏性的疾病。在多种颅内出血动物模型中已确定了预防组织损伤和改善功能结局的神经保护策略。然而，这些潜在干预措施在临床试验中产生的结果总体上令人失望。随着组学技术的进步，对包括基因组学、转录组学、表观遗传学、蛋白质组学、代谢组学和肠道微生物组在内的组学数据的研究可能有助于推动精准医学的发展。在本综述中，我们重点介绍了所有组学在颅内出血中的应用，并阐明了系统分析多种组学技术在颅内出血中的必要性和重要性的所有显著优势。
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