Tung Nguyen Thanh, Lin Shang-Yang, Liu Wen-Te, Kuan Yi-Chun, Wu Chih-Da, Xuan Thao Huynh Nguyen, Dung Hoang Ba, Chung Thuy Tran Phan, Chuang Hsiao-Chi
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan.
Otorhinolaryngology Department, Cho Ray Hospital, Ho Chi Minh City 700000, Vietnam.
ACS Environ Au. 2022 Sep 23;3(1):12-17. doi: 10.1021/acsenvironau.2c00034. eCollection 2023 Jan 18.
We conducted a cross-sectional study to investigate associations of particulate matter (PM) of less than 2.5 μm in aerodynamic diameter (PM) and PM deposition with nocturnal changes in body composition in obstructive sleep apnea (OSA) patients. A bioelectric impedance analysis was used to measure the pre- and postsleep body composition of 185 OSA patients. Annual exposure to PM was estimated by the hybrid kriging/land-use regression model. A multiple-path particle dosimetry model was employed to estimate PM deposition in lung regions. We observed that an increase in the interquartile range (IQR) (1 μg/m) of PM was associated with a 20.1% increase in right arm fat percentage and a 0.012 kg increase in right arm fat mass in OSA ( < 0.05). We observed that a 1 μg/m increase in PM deposition in lung regions (i.e., total lung region, head and nasal region, tracheobronchial region, and alveolar region) was associated with increases in changes of fat percentage and fat mass of the right arm (β coefficient) ( < 0.05). The β coefficients decreased as follows: alveolar region > head and nasal region > tracheobronchial region > total lung region ( < 0.05). Our findings demonstrated that an increase in PM deposition in lung regions, especially in the alveolar region, could be associated with nocturnal changes in the fat percentage and fat mass of the right arm. PM deposition in the alveolar region could accelerate the body fat accumulation in OSA.
我们开展了一项横断面研究，以调查空气动力学直径小于2.5μm的颗粒物（PM）及PM沉积与阻塞性睡眠呼吸暂停（OSA）患者身体成分夜间变化之间的关联。采用生物电阻抗分析法测量了185例OSA患者睡眠前后的身体成分。通过混合克里金/土地利用回归模型估算年度PM暴露量。采用多路径颗粒剂量测定模型估算肺部区域的PM沉积。我们观察到，OSA患者中PM四分位数间距（IQR）增加1μg/m³与右臂脂肪百分比增加20.1%及右臂脂肪量增加0.012kg相关（P<0.05）。我们观察到，肺部区域（即全肺区域、头部和鼻腔区域、气管支气管区域和肺泡区域）的PM沉积每增加1μg/m³与右臂脂肪百分比和脂肪量变化增加相关（β系数）（P<0.05）。β系数按以下顺序降低：肺泡区域>头部和鼻腔区域>气管支气管区域>全肺区域（P<0.05）。我们的研究结果表明，肺部区域尤其是肺泡区域的PM沉积增加可能与右臂脂肪百分比和脂肪量的夜间变化相关。肺泡区域的PM沉积可能会加速OSA患者体内脂肪的积累。
