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精准基因组成瘾医学作为在奖赏缺乏综合征(RDS)中诱导“多巴胺稳态”的一线治疗手段,未来已来。

The Future is Now for Precision Genomic Addiction Medicine as a Frontline Modality for Inducing "Dopamine Homeostasis" in Reward Deficiency Syndrome (RDS).

作者信息

Gilley Elizabeth D, Bowirrat Abdalla, Gupta Ashim, Giordano John, A Dennen Catherine, R Braverman Eric, D Badgaiyan Rajendra, McLaughlin Thomas, Baron David, Blum Kenneth

机构信息

The Elle Foundation, West Palm Beach, Florida, FL, USA.

The Kenneth Blum Institute of Behavior & Neurogenetics, Austin, TX, USA.

出版信息

Curr Pharm Biotechnol. 2023 Apr 27. doi: 10.2174/1389201024666230427111117.

DOI:10.2174/1389201024666230427111117
PMID:37102488
Abstract

INTRODUCTION

In this genomic era of addiction medicine, ideal treatment planning begins with genetic screening to determine neurogenetic antecedents of the Reward Deficiency Syndrome (RDS) phenotype. Patients suffering from endotype addictions, both substance and behavioral, and other mental health/comorbid disorders that share the neurobiological commonality of dopamine dysfunction, are ideal candidates for RDS solutions that facilitate dopamine homeostasis, addressing the cause, rather than symptoms.

OBJECTIVE

Our goal is to promote the interplay of molecular biology and recovery as well as provide evidence linked to RDS and its scientific basis to primary care physicians and others.

METHODS

This was an observational case study with a retrospective chart review in which an RDS treatment plan that utilized Genetic Addiction Risk Severity (GARS) analysis to evaluate neurogenetic challenges was used in order to develop appropriate short- and long-term pharmaceutical and nutraceutical interventions.

RESULTS

A Substance Use Disorder (SUD) treatment-resistant patient was successfully treated utilizing the GARS test and RDS science.

CONCLUSION

The RDS Solution Focused Brief Therapy (RDS-SFBT) and the RDS Severity of Symptoms Scale (SOS) may provide clinicians with a useful tool for establishing neurological balance and helping patients to achieve self-efficacy, self-actualization, and prosperity.

摘要

引言

在成瘾医学的这个基因组时代,理想的治疗规划始于基因筛查,以确定奖赏缺乏综合征(RDS)表型的神经遗传学病因。患有内表型成瘾(包括物质成瘾和行为成瘾)以及其他具有多巴胺功能障碍神经生物学共性的心理健康/共病障碍的患者,是RDS解决方案的理想候选者,这些解决方案有助于多巴胺稳态,解决病因而非症状。

目的

我们的目标是促进分子生物学与康复之间的相互作用,并为初级保健医生和其他人员提供与RDS及其科学依据相关的证据。

方法

这是一项观察性病例研究,采用回顾性病历审查,其中使用了一项利用遗传成瘾风险严重程度(GARS)分析来评估神经遗传学挑战的RDS治疗计划,以制定适当的短期和长期药物及营养干预措施。

结果

一名对物质使用障碍(SUD)治疗耐药的患者通过使用GARS测试和RDS科学方法成功得到治疗。

结论

以RDS解决方案为重点的简短疗法(RDS-SFBT)和RDS症状严重程度量表(SOS)可能为临床医生提供一个有用的工具,用于建立神经平衡,并帮助患者实现自我效能感、自我实现和繁荣。

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