Espiye Vocational School, Giresun University, 28600 Giresun, Turkey.
Biomed Pharmacother. 2023 Jul;163:114788. doi: 10.1016/j.biopha.2023.114788. Epub 2023 Apr 25.
Impaired wound healing is a critical health concern for individuals with diabetes. Sinapic acid, a phyto-compound, has wound-healing potential owing to its various bioactivities. In this study, we explored the wound-healing ability of sinapic acid in diabetes. Full-thickness excisional wounds were created in streptozotocin-induced diabetic rats. Sinapic acid-loaded gels (1%, 2%, and 3%) were prepared and applied topically to diabetic skin wounds. On day 7 post-wounding, rats were sacrificed, and macroscopic, histopathological, and oxidative markers of wound healing activity were evaluated in the collected wound tissues. Sinapic acid-loaded gels showed better recovery in re-epithelialization (p < 0.05) and angiogenesis (p < 0.05) compared to the negative control group. Sinapic acid-loaded gels (1%, 2%, and 3%) showed 87.46%, 79.53%, and 68.78% wound contraction, respectively. They increased collagen content (28.05 ± 1.66, 17.30 ± 2.19, and 11.64 ± 1.25, respectively) and decreased malondialdehyde (MDA) levels (17.49 ± 1.61, 18.44 ± 1.24, and 19.16 ± 1.77, respectively) compared to the negative control group (6.76 ± 0.89, and 43.58 ± 3.70, respectively) (p < 0.05). Moreover, sinapic acid-loaded gel groups demonstrated enhanced antioxidant capacity (approximately 2-2.5-fold) compared to the negative control group (p < 0.05). Sinapic acid 1% loaded gel showed the best effect on the diabetic healing process, whereas sinapic acid 2% loaded gel and reference drug showed similar effects. The results of this study, for the first time, suggest that the topical application of sinapic acid can promote diabetic wound healing, especially at low doses.
伤口愈合受损是糖尿病患者的一个严重健康问题。芥子酸是一种植物化合物，由于其多种生物活性，具有伤口愈合的潜力。在这项研究中，我们探讨了芥子酸在糖尿病中的伤口愈合能力。在链脲佐菌素诱导的糖尿病大鼠中创建全层切除伤口。制备芥子酸负载凝胶（1%、2%和 3%）并局部应用于糖尿病皮肤伤口。在受伤后第 7 天，处死大鼠，评估收集的伤口组织中的宏观、组织病理学和伤口愈合活性的氧化标记物。与阴性对照组相比，芥子酸负载凝胶在再上皮化（p < 0.05）和血管生成（p < 0.05）方面表现出更好的恢复。芥子酸负载凝胶（1%、2%和 3%）的伤口收缩率分别为 87.46%、79.53%和 68.78%。它们增加了胶原蛋白含量（分别为 28.05 ± 1.66、17.30 ± 2.19 和 11.64 ± 1.25）并降低了丙二醛（MDA）水平（分别为 17.49 ± 1.61、18.44 ± 1.24 和 19.16 ± 1.77）与阴性对照组（分别为 6.76 ± 0.89 和 43.58 ± 3.70）（p < 0.05）。此外，与阴性对照组相比，芥子酸负载凝胶组表现出增强的抗氧化能力（约 2-2.5 倍）（p < 0.05）。1%芥子酸负载凝胶对糖尿病愈合过程的效果最佳，而 2%芥子酸负载凝胶和参考药物的效果相似。这项研究的结果首次表明，局部应用芥子酸可以促进糖尿病伤口愈合，特别是在低剂量下。
