Iwate Tohoku Medical Megabank Organization, Iwate Medical University, Shiwa 020-3694, Japan.
Department of Clinical Genetics, School of Medicine, Iwate Medical University, Morioka 020-8505, Japan.
Genes (Basel). 2023 Mar 28;14(4):814. doi: 10.3390/genes14040814.
Knowledge of genetics is essential for understanding the results of genetic testing and its implications. Recent advances in genomic research have allowed us to predict the risk of onset of common diseases based on individual genomic information. It is anticipated that more people will receive such estimates of risks based on their genomic data. However, currently, there is no measure for genetic knowledge that includes post-genome sequencing advancements in Japan. In this study, we translated the genomic knowledge measure in the International Genetics Literacy and Attitudes Survey (iGLAS-GK) into Japanese and validated it in a general Japanese adult population ( = 463). The mean score was 8.41 (SD 2.56, range 3-17). The skewness and kurtosis were 0.534 and 0.088, respectively, and the distribution showed a slightly positive skewness. Exploratory factor analysis proposed a six-factor model. Results for 16 of the 20 items of the Japanese version of the iGLAS-GK were comparable to those from previous studies in other populations. These results indicate that the Japanese version is reliable and can be used to measure the genomic knowledge of adults in the general population, and this version of the knowledge measure maintains the multidimensional structure for assessing genomic knowledge.
了解遗传学对于理解遗传测试的结果及其意义至关重要。基因组研究的最新进展使我们能够根据个体基因组信息预测常见疾病的发病风险。预计会有更多的人根据他们的基因组数据获得这样的风险估计。然而，目前在日本还没有一种衡量遗传知识的方法，包括基因组测序技术的进步。在这项研究中，我们将国际遗传素养和态度调查（iGLAS-GK）中的基因组知识衡量标准翻译成日语，并在一般日本成年人群体中进行了验证（n=463）。平均得分为 8.41（SD 2.56，范围 3-17）。偏度和峰度分别为 0.534 和 0.088，分布呈轻微正偏态。探索性因子分析提出了一个六因素模型。日本版 iGLAS-GK 的 20 个项目中的 16 个项目的结果与其他人群的先前研究结果相当。这些结果表明，日语版是可靠的，可以用来衡量普通人群中成年人的基因组知识，并且该知识衡量标准保持了评估基因组知识的多维结构。
