Department of Gynecology and Obstetrics, University Hospital Centre, 10 000 Zagreb, Croatia.
Medical School, University of Zagreb, 10 000 Zagreb, Croatia.
Medicina (Kaunas). 2023 Apr 3;59(4):700. doi: 10.3390/medicina59040700.
Stress urinary incontinence (SUI) is defined as unintentional urine leakage occurring as a consequence of increased intraabdominal pressure due to absent or weak musculus detrusor contractility. It affects postmenopausal women more often than premenopausal and is associated with quality of life (QoL) deterioration. The complex SUI etiology is generally perceived as multifactorial; however, the overall impact of environmental and genetic influences is deficiently understood. In this research report, we have disclosed the upregulation of 15 genes and the downregulation of 2 genes in the genetic etiology of SUI according to the accessible scientific literature. The analytical methods used for the analysis of gene expression in the studies investigated were immunohistochemistry, immunofluorescence staining, PCR, and Western blot. In order to facilitate the interpretation of the results, we have used GeneMania, a potent software which describes genetic expression, co-expression, co-localization, and protein domain similarity. The importance of this review on the genetic pathophysiology of SUI lies in determining susceptibility for targeted genetic therapy, detecting clinical biomarkers, and other possible therapeutic advances. The prevention of SUI with the timely recognition of genetic factors may be important for avoiding invasive operative urogynecological methods.
压力性尿失禁（SUI）定义为由于腹内压增加而导致的无意识尿液泄漏，这是由于逼尿肌收缩力缺失或减弱引起的。它在绝经后妇女中比绝经前妇女更为常见，并且与生活质量（QoL）恶化有关。SUI 的复杂病因通常被认为是多因素的；然而，环境和遗传影响的总体影响理解不足。在本研究报告中，我们根据可获得的科学文献，揭示了 SUI 遗传病因中 15 个基因的上调和 2 个基因的下调。用于研究中基因表达分析的分析方法是免疫组织化学、免疫荧光染色、PCR 和 Western blot。为了便于解释结果，我们使用了 GeneMania，这是一种强大的软件，用于描述基因表达、共表达、共定位和蛋白质结构域相似性。本综述对 SUI 的遗传病理生理学的重要性在于确定靶向基因治疗的易感性，检测临床生物标志物和其他可能的治疗进展。通过及时识别遗传因素来预防 SUI 对于避免侵入性手术性妇科泌尿科方法可能很重要。
