Pennacchia Fiorenza, Rusi Eqrem, Ruqa Wael Abu, Zingaropoli Maria Antonella, Pasculli Patrizia, Talarico Giuseppina, Bruno Giuseppe, Barbato Christian, Minni Antonio, Tarani Luigi, Galardo Gioacchino, Pugliese Francesco, Lucarelli Marco, Ferraguti Giampiero, Ciardi Maria Rosa, Fiore Marco
Department of Sensory Organs, Sapienza University of Rome, 00185 Roma, Italy.
Department of Human Neuroscience, Sapienza University of Rome, 00185 Rome, Italy.
Microorganisms. 2023 Apr 2;11(4):925. doi: 10.3390/microorganisms11040925.
Since its outbreak, Coronavirus disease 2019 (COVID-19), a life-threatening respiratory illness, has rapidly become a public health emergency with a devastating social impact. Lately, the Omicron strain is considered the main variant of concern. Routine blood biomarkers are, indeed, essential for stratifying patients at risk of severe outcomes, and a huge amount of data is available in the literature, mainly for the previous variants. However, only a few studies are available on early routine biochemical blood biomarkers for Omicron-afflicted patients. Thus, the aim and novelty of this study were to identify routine blood biomarkers detected at the emergency room for the early prediction of severe morbidity and/or mortality.
449 COVID-19 patients from Sapienza University Hospital of Rome were divided into four groups: (1) the group (patients with mild forms who were quickly discharged); (2) the group (patients that after the admission in the emergency department were hospitalized in a COVID-19 ward); (3) the intensive care unit () group (patients that after the admission in the emergency department required intensive assistance); (4) the group (patients that after the admission in the emergency department had a fatal outcome).
ANOVA and ROC data showed that high-sensitivity troponin-T (TnT), fibrinogen, glycemia, C-reactive protein, lactate dehydrogenase, albumin, D-dimer myoglobin, and ferritin for both men and women may predict lethal outcomes already at the level of the emergency department.
Compared to previous Delta COVID-19 parallel emergency patterns of prediction, Omicron-induced changes in TnT may be considered other early predictors of severe outcomes.
自2019年冠状病毒病（COVID-19）爆发以来，这种危及生命的呼吸系统疾病迅速演变成一场具有毁灭性社会影响的公共卫生紧急事件。最近，奥密克戎毒株被认为是主要的关注变种。常规血液生物标志物确实对于对有严重后果风险的患者进行分层至关重要，并且文献中有大量数据，主要针对先前的变种。然而，关于奥密克戎感染患者的早期常规生化血液生物标志物的研究仅有少数。因此，本研究的目的和新颖之处在于识别在急诊室检测到的常规血液生物标志物，用于早期预测严重发病和/或死亡。
来自罗马萨皮恩扎大学医院的449名COVID-19患者被分为四组：（1）轻症组（症状轻微且很快出院的患者）；（2）住院组（在急诊科就诊后被收治到COVID-19病房的患者）；（3）重症监护病房（ICU）组（在急诊科就诊后需要重症监护的患者）；（4）死亡组（在急诊科就诊后出现致命结局的患者）。
方差分析和ROC数据表明，高敏肌钙蛋白-T（TnT）、纤维蛋白原、血糖、C反应蛋白、乳酸脱氢酶、白蛋白、D-二聚体、肌红蛋白和铁蛋白，无论男性还是女性，在急诊科水平就可能预测致命结局。
与先前Delta COVID-19的平行急诊预测模式相比，奥密克戎引起的TnT变化可能被视为严重后果的其他早期预测指标。
