Zhao Fuju, Hu Xianyang, Ying Chunmei
Clinical Laboratory, Huadong Hospital, Fudan University, Shanghai 200031, China.
Clinical Laboratory, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China.
Microorganisms. 2023 Apr 11;11(4):991. doi: 10.3390/microorganisms11040991.
The human microbiota inhabiting different parts of the body has been shown to have a significant impact on human health, with the gut microbiota being the most extensively studied in relation to disease. However, the vaginal microbiota is also an essential commensal microbiota in the female body that plays a crucial role in female health. Despite receiving less attention than gut microbiota, its importance in regulating reproductive immunity and its complex dynamic properties have been increasingly recognized in recent years. Advances in research on the relationship between vaginal microbiota and pregnancy outcomes & gynecological diseases in women have shed light on the importance of maintaining a healthy vaginal microbiota. In this review, we aim to compile recent developments in the study of the vaginal microbial ecosystem and its role in female health and reproductive outcomes. We provide a comprehensive account of the normal vaginal microbiota, the association between the vaginal microbiota and pregnancy outcomes, and the impact of the vaginal microbiota on gynecological diseases in women. By reviewing recent research, we hope to contribute to the advancement of academic medicine's understanding of the vaginal microbiota's importance in female health. We also aim to raise awareness among healthcare professionals and the general public of the significance of maintaining a healthy vaginal microbiota for better reproductive health and the prevention of gynecological diseases.
居住在人体不同部位的微生物群已被证明对人类健康有重大影响，其中肠道微生物群在疾病方面的研究最为广泛。然而，阴道微生物群也是女性体内重要的共生微生物群，对女性健康起着关键作用。尽管它受到的关注不如肠道微生物群，但近年来其在调节生殖免疫方面的重要性及其复杂的动态特性已得到越来越多的认可。阴道微生物群与女性妊娠结局和妇科疾病之间关系的研究进展揭示了维持健康阴道微生物群的重要性。在这篇综述中，我们旨在汇总阴道微生物生态系统研究的最新进展及其在女性健康和生殖结局中的作用。我们全面阐述了正常阴道微生物群、阴道微生物群与妊娠结局之间的关联，以及阴道微生物群对女性妇科疾病的影响。通过回顾近期研究，我们希望推动学术医学对阴道微生物群在女性健康中重要性的理解。我们还旨在提高医疗保健专业人员和公众对维持健康阴道微生物群对于改善生殖健康和预防妇科疾病重要性的认识。
