Mikami Katsunaka, Watanabe Natsuru, Tochio Takumi, Kimoto Keitaro, Akama Fumiaki, Yamamoto Kenji
Department of Psychiatry, Tokai University School of Medicine, Isehara 259-1193, Kanagawa, Japan.
Department of Gastroenterology and Hepatology, Fujita Health University, Toyoake 470-1192, Aichi, Japan.
Microorganisms. 2023 Apr 12;11(4):1008. doi: 10.3390/microorganisms11041008.
Aggression in the animal kingdom is a necessary component of life; however, certain forms of aggression, especially in humans, are pathological behaviors that are detrimental to society. Animal models have been used to study a number of factors, including brain morphology, neuropeptides, alcohol consumption, and early life circumstances, to unravel the mechanisms underlying aggression. These animal models have shown validity as experimental models. Moreover, recent studies using mouse, dog, hamster, and drosophila models have indicated that aggression may be affected by the "microbiota-gut-brain axis." Disturbing the gut microbiota of pregnant animals increases aggression in their offspring. In addition, behavioral analyses using germ-free mice have shown that manipulating the intestinal microbiota during early development suppresses aggression. These studies suggest that treating the host gut microbiota during early development is critical. However, few clinical studies have investigated gut-microbiota-targeted treatments with aggression as a primary endpoint. This review aims to clarify the effects of gut microbiota on aggression and discusses the therapeutic potential of regulating human aggression by intervening in gut microbiota.
动物王国中的攻击行为是生命的必要组成部分；然而，某些形式的攻击行为，尤其是人类的攻击行为，是对社会有害的病理行为。动物模型已被用于研究许多因素，包括脑形态、神经肽、酒精摄入和早期生活环境，以揭示攻击行为背后的机制。这些动物模型已证明作为实验模型的有效性。此外，最近使用小鼠、狗、仓鼠和果蝇模型的研究表明，攻击行为可能受“微生物群-肠道-脑轴”影响。扰乱怀孕动物的肠道微生物群会增加其后代的攻击性。此外，使用无菌小鼠的行为分析表明，在早期发育过程中操纵肠道微生物群可抑制攻击性。这些研究表明，在早期发育过程中治疗宿主肠道微生物群至关重要。然而，很少有临床研究以攻击行为作为主要终点来研究针对肠道微生物群的治疗方法。本综述旨在阐明肠道微生物群对攻击行为的影响，并讨论通过干预肠道微生物群来调节人类攻击行为的治疗潜力。
