State Key Laboratory of Biocatalysis and Enzyme Engineering, Hubei Province Key Laboratory of Biotechnology of Chinese Traditional Medicine, National & Local Joint Engineering Research Center of High-throughput Drug Screening Technology, School of life science, Hubei University, Wuhan, China.
Department of Medical Laboratory Science, Fenyang College, Shanxi Medical University, Shanxi, China.
Nat Commun. 2021 May 11;12(1):2698. doi: 10.1038/s41467-021-23041-y.
Gut microbiome profoundly affects many aspects of host physiology and behaviors. Here we report that gut microbiome modulates aggressive behaviors in Drosophila. We found that germ-free males showed substantial decrease in inter-male aggression, which could be rescued by microbial re-colonization. These germ-free males are not as competitive as wild-type males for mating with females, although they displayed regular levels of locomotor and courtship behaviors. We further found that Drosophila microbiome interacted with diet during a critical developmental period for the proper expression of octopamine and manifestation of aggression in adult males. These findings provide insights into how gut microbiome modulates specific host behaviors through interaction with diet during development.
肠道微生物组深刻地影响着宿主生理和行为的许多方面。在这里，我们报告肠道微生物组调节果蝇的攻击行为。我们发现无菌雄性果蝇的雄性间攻击行为显著减少，而微生物再定植可挽救这种行为。这些无菌雄性果蝇与野生型雄性相比，在与雌性交配时竞争力较弱，尽管它们表现出正常水平的运动和求偶行为。我们进一步发现，在成年雄性中，果蝇微生物组与饮食相互作用，在一个关键的发育时期影响章鱼胺的表达和攻击行为的表现。这些发现为肠道微生物组如何通过与饮食在发育过程中的相互作用来调节特定的宿主行为提供了新的视角。
