Department of Organic and Physical Chemistry, Faculty of Pharmacy, Medical University of Warsaw, Banacha 1, 02-097 Warsaw, Poland.
Molecules. 2023 Apr 13;28(8):3442. doi: 10.3390/molecules28083442.
Turmeric is a traditional Indian spice that has recently become very popular worldwide because it contains a powerful ingredient called curcumin, which has strong anti-inflammatory properties. Hence, dietary supplements containing extracts rich in curcumin have gained great popularity. The main problems related to curcumin-containing dietary supplements are poor water solubility and the fact that they are often faked by using synthetic curcumin instead of the plant extract. In this article, we propose the use of the C CPMAS NMR method to control the quality of dietary supplements. The analysis of C CPMAS NMR spectra supported by GIPAW computations allowed us to identify a polymorphic form present in dietary supplements (which affected the solubility of curcumin) and to point out a dietary supplement that could be faked by using synthetic curcumin. Further PXRD and HPLC investigations confirmed that the examined supplement contained synthetic curcumin instead of the genuine extract. Our method can be used for routine control, especially because the investigation is performed directly from the capsule/tablet content and does not require any special sample preparation.
姜黄是一种传统的印度香料，近年来在全球范围内变得非常流行，因为它含有一种叫做姜黄素的有效成分，具有很强的抗炎特性。因此，含有姜黄素提取物的膳食补充剂变得非常受欢迎。含姜黄素膳食补充剂的主要问题是水溶性差，而且经常使用合成姜黄素代替植物提取物来造假。在本文中，我们提出使用 C CPMAS NMR 方法来控制膳食补充剂的质量。通过 GIPAW 计算支持的 C CPMAS NMR 光谱分析，我们能够鉴定出膳食补充剂中存在的多晶型形式（这会影响姜黄素的溶解度），并指出一种可能使用合成姜黄素造假的膳食补充剂。进一步的 PXRD 和 HPLC 研究证实，所检查的补充剂含有合成姜黄素，而不是真正的提取物。我们的方法可用于常规控制，特别是因为该研究是直接从胶囊/片剂内容物进行的，不需要任何特殊的样品制备。
