Department of Human Nutrition, The Ohio State University, 345 Campbell Hall, 1787 Neil Ave, Columbus, OH 43210-1295, USA.
Nutr J. 2012 Sep 26;11:79. doi: 10.1186/1475-2891-11-79.
Curcumin extracts of turmeric are proposed to produce health benefits. To date, human intervention studies have focused mainly on people with existing health problems given high doses of poorly absorbed curcumin. The purpose of the current study was to check whether in healthy people, a low dose of a lipidated curcumin extract could alter wellness-related measures.
The present study was conducted in healthy middle aged people (40-60 years old) with a low dose of curcumin (80 mg/day) in a lipidated form expected to have good absorption. Subjects were given either curcumin (N = 19) or placebo (N = 19) for 4 wk. Blood and saliva samples were taken before and after the 4 weeks and analyzed for a variety of blood and saliva measures relevant to health promotion.
Curcumin, but not placebo, produced the following statistically significant changes: lowering of plasma triglyceride values, lowering of salivary amylase levels, raising of salivary radical scavenging capacities, raising of plasma catalase activities, lowering of plasma beta amyloid protein concentrations, lowering of plasma sICAM readings, increased plasma myeloperoxidase without increased c-reactive protein levels, increased plasma nitric oxide, and decreased plasma alanine amino transferase activities.
Collectively, these results demonstrate that a low dose of a curcumin-lipid preparation can produce a variety of potentially health promoting effects in healthy middle aged people.
姜黄中的姜黄素提取物据称具有健康益处。迄今为止，人类干预研究主要集中在患有现有健康问题的人群身上，这些人接受了高剂量、吸收不良的姜黄素治疗。本研究的目的是检查在健康人群中，低剂量的脂质化姜黄素提取物是否能改变与健康相关的指标。
本研究在健康的中年人群（40-60 岁）中进行，他们服用低剂量的脂质化姜黄素（80mg/天），预计吸收良好。受试者服用姜黄素（N=19）或安慰剂（N=19），持续 4 周。在 4 周前后采集血液和唾液样本，并分析与健康促进相关的各种血液和唾液指标。
姜黄素而非安慰剂产生了以下具有统计学意义的变化：降低血浆甘油三酯值、降低唾液淀粉酶水平、提高唾液自由基清除能力、提高血浆过氧化氢酶活性、降低血浆β淀粉样蛋白浓度、降低血浆可溶性细胞间黏附分子读数、增加血浆髓过氧化物酶而不增加 C 反应蛋白水平、增加血浆一氧化氮、降低血浆丙氨酸氨基转移酶活性。
综上所述，这些结果表明，低剂量的姜黄素脂质制剂可以在健康的中年人群中产生多种潜在的健康促进作用。
