School of Materials Science and Engineering, South China University of Technology, Guangzhou, 510641, China.
J Mater Chem B. 2019 Mar 14;7(10):1637-1651. doi: 10.1039/c8tb02547a. Epub 2019 Jan 3.
Self-healing is one of the most fundamental properties of living tissues that allows them to withstand repeated damage. Self-healing hydrogels, which can spontaneously recover themselves after being ruptured, result in enhanced lifetimes for materials and open up a fascinating direction in materials science. Host-guest interactions have been widely used in the construction of self-healing hydrogels. We have emphasized the preparation and biomedical applications of self-healing hydrogels assembled by host-guest interactions, focusing on hosts of cyclodextrins and cucurbit[n]urils with various guests and tailored structures. The applications of self-healing hydrogels in biomedical fields such as drug delivery, encapsulation of cells and tissue engineering and 3D printing as well as interfacial adhesion were also summarized. At the end of this review, we propose the current challenges and future perspectives in this developing area.
自修复是活体组织的最基本特性之一，它使活体组织能够承受反复的损伤。自修复水凝胶在破裂后可以自发地恢复自身，从而延长了材料的使用寿命，并为材料科学开辟了一个引人入胜的方向。主体-客体相互作用已广泛应用于自修复水凝胶的构建中。我们强调了通过主体-客体相互作用组装的自修复水凝胶的制备和生物医学应用，重点介绍了具有各种客体和定制结构的环糊精和瓜环主体。自修复水凝胶在药物输送、细胞和组织工程封装以及 3D 打印以及界面粘附等生物医学领域的应用也得到了总结。在这篇综述的最后，我们提出了这一快速发展领域当前的挑战和未来展望。
