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发展“应用蛋白质组学”概念以应用于微藻生物技术:以蛋白质组数据为例。

Development of the "Applied Proteomics" Concept for Biotechnology Applications in Microalgae: Example of the Proteome Data in .

机构信息

Microbiology Laboratory, Institute of Viticulture and Agri-Food Research (IVAGRO), Marine and Environmental Sciences Faculty, University of Cadiz (UCA), 11500 Puerto Real, Spain.

出版信息

Mar Drugs. 2021 Dec 29;20(1):38. doi: 10.3390/md20010038.

DOI:10.3390/md20010038
PMID:35049892
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8780095/
Abstract

Most of the marine ecosystems on our planet are still unknown. Among these ecosystems, microalgae act as a baseline due to their role as primary producers. The estimated millions of species of these microorganisms represent an almost infinite source of potentially active biocomponents offering unlimited biotechnology applications. This review considers current research in microalgae using the "omics" approach, which today is probably the most important biotechnology tool. These techniques enable us to obtain a large volume of data from a single experiment. The specific focus of this review is proteomics as a technique capable of generating a large volume of interesting information in a single proteomics assay, and particularly the concept of applied proteomics. As an example, this concept has been applied to the study of , in which proteomics data generated are transformed into information of high commercial value by identifying proteins with direct applications in the biomedical and agri-food fields, such as the protein designated UCA01 which presents antitumor activity, obtained from .

摘要

地球上大多数海洋生态系统仍然未知。在这些生态系统中,微藻作为初级生产者起着基准作用。这些微生物估计有上百万种,代表着潜在的、具有活性的生物成分的几乎无限来源,为生物技术提供了无限的应用。本综述考虑了当前使用“组学”方法的微藻研究,这可能是当今最重要的生物技术工具。这些技术使我们能够从单个实验中获得大量数据。本综述的具体重点是蛋白质组学,作为一种能够在单个蛋白质组学分析中产生大量有趣信息的技术,特别是应用蛋白质组学的概念。例如,该概念已应用于 的研究,通过鉴定在生物医学和农业食品领域具有直接应用的蛋白质,将蛋白质组学数据转化为具有高商业价值的信息,例如从 中获得的具有抗肿瘤活性的蛋白质 UCA01。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/bb1886ed369c/marinedrugs-20-00038-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/3d8119dbe87d/marinedrugs-20-00038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/7c2f37c51349/marinedrugs-20-00038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/bb1886ed369c/marinedrugs-20-00038-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/3d8119dbe87d/marinedrugs-20-00038-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/7c2f37c51349/marinedrugs-20-00038-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b2/8780095/bb1886ed369c/marinedrugs-20-00038-g003.jpg

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本文引用的文献

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