Lopez Robert N, Leach Steven T, Bowcock Nerissa, Coker Elise, Shapiro Amanda J, Day Andrew S, Lemberg Daniel A
Department of Gastroenterology, Sydney Children's Hospital, Sydney 2031, Australia.
Department of Paediatrics, School of Clinical Medicine, University of NSW, Sydney 2052, Australia.
Pathogens. 2023 Apr 12;12(4):585. doi: 10.3390/pathogens12040585.
The role of gastrointestinal microbiome in health and disease is increasingly appreciated. A significant amount of evidence clearly points to a dysbiosis manifest in inflammatory bowel disease (IBD) when compared to healthy controls. Less understood is the microbiome profile in autoimmune liver disease (AILD). Both adult and paediatric data indicate a distinct microbial signature in patients with IBD and co-existent primary sclerosing cholangitis (PSC), which is unique and different compared to the microbial signature that exists in patients with IBD alone. However, there is limited information on the microbiome make-up of patients with parenchymal liver disease, with or without IBD.
The present study sought to compare the microbiome of children with IBD, to those with IBD-AILD, those with AILD alone and those of healthy controls.
Results from this work indicate that children with AILD have a microbiome profile that mirrors healthy controls.
Those with IBD-AILD and IBD have similar microbiome profiles which are distinct from AILD alone and healthy controls. This suggests that the dysbiosis in these groups is primarily due to IBD rather than AILD.
胃肠道微生物群在健康和疾病中的作用越来越受到重视。大量证据清楚地表明，与健康对照相比，炎症性肠病（IBD）中存在微生物群落失调。自身免疫性肝病（AILD）中的微生物群特征则了解较少。成人和儿科数据均表明，IBD合并原发性硬化性胆管炎（PSC）患者具有独特的微生物特征，与仅患有IBD的患者的微生物特征相比是独特且不同的。然而，关于有或没有IBD的实质性肝病患者的微生物群组成的信息有限。
本研究旨在比较IBD儿童、IBD-AILD儿童、单纯AILD儿童和健康对照儿童的微生物群。
这项研究的结果表明，AILD儿童的微生物群特征与健康对照相似。
IBD-AILD患者和IBD患者具有相似的微生物群特征，这与单纯AILD患者和健康对照不同。这表明这些组中的微生物群落失调主要是由于IBD而非AILD。
