Kenmoe Sebastien, Tchendjou Patrice, Vernet Marie-Astrid, Moyo-Tetang Suzie, Mossus Tatiana, Njankouo-Ripa Mohamadou, Kenne Angeladine, Penlap Beng Véronique, Vabret Astrid, Njouom Richard
Centre Pasteur of Cameroon, International Network of Pasteur Institutes, Yaounde, Cameroon.
Département de Biochimie, Université de Yaoundé 1, Yaounde, Cameroun.
Influenza Other Respir Viruses. 2016 Sep;10(5):386-93. doi: 10.1111/irv.12391. Epub 2016 May 9.
Severe acute respiratory illness (SARI) is recognized as an important cause of morbidity, mortality, and hospitalization among children in developing countries. Little is known, however, in tropical countries like Cameroon about the cause and seasonality of respiratory infections, especially in hospitalized settings.
Our study investigates the viral etiology and seasonality of SARI in hospitalized children in Yaounde, Cameroon.
Prospective clinic surveillance was conducted to identify hospitalized children aged ≤15 years presenting with respiratory symptoms ≤5-day duration. Demographic and clinical data, and respiratory specimens were collected. Nasopharyngeal samples were tested for 17 respiratory viruses using a multiplex polymerase chain reaction. The viral distribution and demographic data were statistically analyzed.
From September 2011 through September 2013, 347 children aged ≤15 years were enrolled. At least one virus was identified in each of 65·4% children, of which 29·5% were coinfections; 27·3% were positive for human adenovirus (hAdV), 13·2% for human respiratory syncytial virus (hRSV), 11·5% for rhinovirus/enterovirus (RV/EV), 10·6% for human bocavirus (hBoV), 9·8% for influenza virus (Inf), 6·6% for human parainfluenza virus (hPIV), 5·7% for human coronavirus (hCoV), and 2·3% for human metapneumovirus (hMPV). While hRSV showed seasonal patterns, hAdV and RV/EV were detected throughout the year and no evident temporal patterns were observed for the remaining viruses.
Respiratory viruses were associated with a high burden of hospitalizations among children in Cameroon. Nevertheless, additional studies evaluating asymptomatic Cameroonian children will be important in understanding the relationship between viral carriage and disease.
严重急性呼吸道疾病（SARI）被认为是发展中国家儿童发病、死亡和住院的重要原因。然而，在喀麦隆这样的热带国家，对于呼吸道感染的病因和季节性，尤其是在住院环境中的情况，人们了解甚少。
我们的研究调查喀麦隆雅温得住院儿童中SARI的病毒病因和季节性。
进行前瞻性临床监测，以确定年龄≤15岁、出现呼吸道症状且病程≤5天的住院儿童。收集人口统计学和临床数据以及呼吸道标本。使用多重聚合酶链反应对鼻咽样本进行17种呼吸道病毒检测。对病毒分布和人口统计学数据进行统计分析。
2011年9月至2013年9月，纳入了347名年龄≤15岁的儿童。65.4%的儿童中至少检测到一种病毒，其中29.5%为混合感染；27.3%的儿童人腺病毒（hAdV）呈阳性，13.2%为人呼吸道合胞病毒（hRSV），11.5%为鼻病毒/肠道病毒（RV/EV），10.6%为人博卡病毒（hBoV），9.8%为流感病毒（Inf），6.6%为人副流感病毒（hPIV），5.7%为人冠状病毒（hCoV），2.3%为人偏肺病毒（hMPV）。虽然hRSV呈现季节性模式，但hAdV和RV/EV全年均可检测到，其余病毒未观察到明显的时间模式。
呼吸道病毒与喀麦隆儿童的高住院负担相关。然而，评估喀麦隆无症状儿童的更多研究对于理解病毒携带与疾病之间的关系将很重要。
