Harrison W M, Rabkin J G, Ehrhardt A A, Stewart J W, McGrath P J, Ross D, Quitkin F M
J Clin Psychopharmacol. 1986 Jun;6(3):144-9.
There has been little systematic study of the types of sexual dysfunction produced by antidepressant medication or of the frequency with which this type of adverse effect occurs. The authors report results of a double-blind study in which the effects of imipramine, phenelzine, and placebo on specific aspects of sexual function were assessed in depressed outpatients before and after 6 weeks of treatment. Both active treatments were associated with a high incidence of adverse changes in sexual function and produced significantly more adverse effects on sexual function than placebo. Orgasm and ejaculation were impaired to a greater extent than erection. Adverse sexual function changes secondary to antidepressant medication occurred frequently in both men and women, although men reported a higher incidence. Antidepressant-related sexual dysfunction may be of clinical importance for medication compliance in view of current recommendations that antidepressants be administered for longer periods as maintenance therapy or for prophylaxis.
对于抗抑郁药物所致性功能障碍的类型，或这种不良反应发生的频率，几乎没有系统的研究。作者报告了一项双盲研究的结果，在该研究中，对抑郁症门诊患者在治疗6周前后，评估了丙咪嗪、苯乙肼和安慰剂对性功能特定方面的影响。两种活性治疗均与性功能不良变化的高发生率相关，且对性功能产生的不良反应明显多于安慰剂。性高潮和射精功能受损的程度大于勃起功能。抗抑郁药物继发的性功能不良变化在男性和女性中均频繁发生，尽管男性报告的发生率更高。鉴于目前关于将抗抑郁药作为维持治疗或预防用药而长期给药的建议，与抗抑郁药相关的性功能障碍可能对药物依从性具有临床重要性。
