Huang Zhi-Fa, Zhu Wei, Wang Chen, Mo Li-Dong, Huang Hui-Ling, Tong Xiao-Guang
Clinical College of Neurology, Neurosurgery and Neurorehabilitation, Tianjin Medical University, Tianjin, China.
Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Evid Based Complement Alternat Med. 2023 Apr 18;2023:8808422. doi: 10.1155/2023/8808422. eCollection 2023.
Gliomas are the most common malignant tumors of the central nervous system. However, the inherited genetic variation in gliomas is presently unclear. Therefore, this study investigated the association of the rs2071559 and rs2239702 gene polymorphisms with glioma susceptibility in Chinese patients.
In this study, a case-control approach was used to compare and analyze whether two genes, rs2071559 and rs2239702, were associated with the risk of glioma formation.
The cases and controls were matched for sex, smoking status, and family history of cancer using single nucleotide polymorphisms. Specific rs2071559 and rs2239702 alleles were found much more frequently in the glioma group than in the control group ( < 0.001 and = 0.014, respectively).
These findings suggest that specific rs2071559 and rs2239702 polymorphisms are associated with a higher risk of glioma development; the risk allele is C in rs2071559 or A in rs2239702. Moreover, the kinase-insert-domain-containing receptor may act as a suppressor of tumor progression.
胶质瘤是中枢神经系统最常见的恶性肿瘤。然而，目前胶质瘤的遗传基因变异尚不清楚。因此，本研究调查了rs2071559和rs2239702基因多态性与中国胶质瘤患者易感性的关系。
在本研究中，采用病例对照方法比较和分析rs2071559和rs2239702这两个基因是否与胶质瘤形成风险相关。
利用单核苷酸多态性对病例组和对照组的性别、吸烟状况和癌症家族史进行匹配。发现特定的rs2071559和rs2239702等位基因在胶质瘤组中的出现频率远高于对照组（分别为<0.001和=0.014）。
这些发现表明，特定的rs2071559和rs2239702多态性与较高的胶质瘤发生风险相关；rs2071559中的风险等位基因为C，rs2239702中的风险等位基因为A。此外，含激酶插入结构域受体可能作为肿瘤进展的抑制因子。
