Xu Guo-Zheng, Liu Ying, Zhang Yi, Yu Jing, Diao Bo
Department of Neurosurgery, Wuhan General Hospital of Guangzhou Command, Hubei Key Laboratory of Central Nervous System Tumor and Intervention Wuhan 430070, China.
Department of Clinical Laboratory, Wuhan General Hospital of Guangzhou Command Wuhan 430070, China.
Int J Clin Exp Med. 2015 Sep 15;8(9):16724-8. eCollection 2015.
We investigated the correlation between vascular endothelial growth factor 2 (VEGFR2) polymorphism and glioma risk among Chinese population.
Case-control study design was adopted, and blood samples and clinical data of 250 glioma cases and 260 control subjects were collected. Epidemiological questionnaire survey was performed, and DNA extraction, concentration normalization and packaging were carried out using Qiagen Blood Kit. TaqMan method was performed for VEGFR2 rs2071559 genotyping.
C allele of VEGFR2 rs2071559 genotype was the susceptibility allele contributing to the risk of glioma (OR=1.813, 95% CI: 1.393-2.359, P=0.014). CC genotypes of VEGFR2 rs2071559 were associated with increased risk of glioma (OR=2.068, 95% CI: 1.164-3.674, P=0.014; Adjusted OR=1.883, 95% CI: 1.430~3.013, P=0.018).
CC genotypes of VEGFR2 rs2071559 were associated with glioma risk among Chinese population. However, the role of VEGFR2 rs2071559 polymorphism in glioma susceptibility remains to be further clarified.
我们研究了中国人群中血管内皮生长因子2（VEGFR2）基因多态性与胶质瘤风险之间的相关性。
采用病例对照研究设计，收集了250例胶质瘤患者和260例对照者的血样及临床数据。进行了流行病学问卷调查，并使用Qiagen血液试剂盒进行DNA提取、浓度标准化和包装。采用TaqMan方法对VEGFR2 rs2071559进行基因分型。
VEGFR2 rs2071559基因型的C等位基因是导致胶质瘤风险的易感等位基因（OR=1.813，95%CI：1.393-2.359，P=0.014）。VEGFR2 rs2071559的CC基因型与胶质瘤风险增加相关（OR=2.068，95%CI：1.164-3.674，P=0.014；校正OR=1.883，95%CI：1.430~3.013，P=0.018）。
VEGFR2 rs2071559的CC基因型与中国人群的胶质瘤风险相关。然而，VEGFR2 rs2071559基因多态性在胶质瘤易感性中的作用仍有待进一步阐明。
