Prasetiyo Patricia Diana, Wahjoepramono Eka Julianta
Department of Pathology, Faculty of Medicine, Pelita Harapan University, Tangerang 15811, Indonesia.
Department of Neurosurgery, Faculty of Medicine, Pelita Harapan University, Tangerang 15811, Indonesia.
J Clin Med. 2024 Jul 25;13(15):4332. doi: 10.3390/jcm13154332.
A glioma is a form of tumor that is abundant in blood vessels. Vascular endothelial growth factor receptor (VEGFR) and its receptor 2 (VEGFR2) are important in the process of angiogenesis. The relationship between VEGFR2 rs2071559 and glioma development is currently uncertain. The present study aims to analyze the correlation between VEGFR2 rs2071559 gene polymorphism and the susceptibility to gliomas.
A thorough search was carried out in the Cochrane Library, Scopus, and Medline databases from inception until 20 February 2024 using a mix of pertinent keywords. We used random-effects models to examine the odds ratio (OR) and reported the results together with their respective 95% confidence intervals (CIs).
A total of six studies were incorporated. The results of our meta-analysis indicated that all genetic models of VEGFR2 rs2071559 gene polymorphism, starting from dominant (OR 1.40; < 0.00001), recessive (OR 1.52; < 0.0001), CC genotype (OR 1.78; < 0.00001), CT genotype (OR 1.30; < 0.0001), and C allele (OR 1.41; < 0.00001), were associated with a higher risk of developing gliomas. The subgroup analysis revealed a higher OR for studies with a sample size of ≥500, originated from Asia, with a mean age of ≥42.3 years, and a male prevalence of <57%.
This study suggests that VEGFR2 rs2071559 gene polymorphism is associated with a higher risk of gliomas.
胶质瘤是一种血管丰富的肿瘤形式。血管内皮生长因子受体（VEGFR）及其受体2（VEGFR2）在血管生成过程中起重要作用。目前，VEGFR2 rs2071559与胶质瘤发生之间的关系尚不确定。本研究旨在分析VEGFR2 rs2071559基因多态性与胶质瘤易感性之间的相关性。
从数据库建立至2024年2月20日，使用相关关键词组合在Cochrane图书馆、Scopus和Medline数据库中进行全面检索。我们使用随机效应模型来检验比值比（OR），并报告结果及其各自的95%置信区间（CI）。
共纳入六项研究。我们的荟萃分析结果表明，VEGFR2 rs2071559基因多态性的所有遗传模型，从显性（OR 1.40；<0.00001）、隐性（OR 1.52；<0.0001）、CC基因型（OR 1.78；<0.00001）、CT基因型（OR 1.30；<0.0001）和C等位基因（OR 1.41；<0.00001）来看，均与患胶质瘤的较高风险相关。亚组分析显示，样本量≥500、来自亚洲、平均年龄≥42.3岁且男性患病率<57%的研究具有更高的OR值。
本研究表明VEGFR2 rs2071559基因多态性与患胶质瘤的较高风险相关。
