Departamento de Oftalmología, Complejo Asistencial de Ávila (Ávila) y Hospital del Río Hortega (Valladolid), Ávila, Spain.
Instituto de Oftalmobiología Aplicada (IOBA), Universidad de Valladolid, Paseo de Belén 17, 47011, Valladolid, Spain.
Graefes Arch Clin Exp Ophthalmol. 2023 Oct;261(10):2853-2861. doi: 10.1007/s00417-023-06080-7. Epub 2023 Apr 28.
To assess the relationship between anterior chamber depth (ACD) and lens thickness (LT), as well as its three main components (anterior and posterior cortex and nucleus thickness), in cataractous and non-cataractous eyes, depending on the axial length (AxL).
Anterior and posterior cortex and nucleus thickness of the crystalline lens, ACD, and AxL were measured using optical low-coherence reflectometry in cataractous and non-cataractous eyes. They were also classified into hyperopia, emmetropia, myopia, and high myopia, depending on AxL; thus, eight subgroups were created. A minimum sample size of 44 eyes (of 44 patients) for each group was recruited. Linear models were fitted for the whole sample and each AxL subgroup to assess if there were differences in the relationships between the crystalline lens variables and ACD, including age as a covariate.
Three hundred seventy cataract patients (237 females, 133 males) and 250 non-cataract controls (180 females, 70 males), aged 70.5 ± 9.4 and 41.9 ± 15.5 years, respectively, were recruited. The mean AxL, ACD, and LT for the cataractous and non-cataractous eyes were 23.90 ± 2.05, 24.11 ± 2.11, 2.64 ± 0.45, and 2.91 ± 0.49, 4.51 ± 0.38, 3.93 ± 0.44 mm, respectively. The inverse relationship of LT, anterior and posterior cortex, and nucleus thickness with ACD was not significantly (p ≥ 0.26) different between cataractous and non-cataractous eyes. Further subclassification of the sample depending on AxL showed that the inverse relationship between the posterior cortex and ACD was no longer significant (p > 0.05) for any non-cataractous AxL group. LT, anterior and posterior cortex, and nucleus thickness was not significantly (p ≥ 0.43) different between cataractous and non-cataractous eyes for the whole sample, and all AxL groups after adjusting for age.
The presence of cataracts does not modify the inverse relationship of the LT, anterior and posterior cortex, and nucleus with ACD. And this relationship does not seem to depend importantly on AxL. Besides, the possible differences in LT, anterior and posterior cortex, and nucleus between cataractous and non-cataractous eyes may not be caused by lens opacification, but possibly by the progressive lens growth due to aging.
评估白内障和非白内障眼的前房深度（ACD）与晶状体厚度（LT）以及晶状体的三个主要成分（前、后皮质和核厚度）之间的关系，并根据眼轴长度（AxL）进行分析。
使用光学低相干反射仪测量白内障和非白内障眼中晶状体的前、后皮质和核厚度、ACD 和 AxL，并根据 AxL 将其分为远视、正视、近视和高度近视，从而创建了 8 个亚组。每个亚组招募了至少 44 只眼（44 例患者）的最小样本量。对整个样本和每个 AxL 亚组进行线性模型拟合，以评估晶状体变量与 ACD 之间的关系是否存在差异，包括年龄作为协变量。
共招募了 370 名白内障患者（237 名女性，133 名男性）和 250 名非白内障对照者（180 名女性，70 名男性），年龄分别为 70.5±9.4 和 41.9±15.5 岁。白内障眼和非白内障眼中的平均 AxL、ACD 和 LT 分别为 23.90±2.05、24.11±2.11、2.64±0.45 和 2.91±0.49、4.51±0.38、3.93±0.44mm。ACD 与 LT、前皮质、后皮质和核厚度之间的负相关关系在白内障眼和非白内障眼中没有显著差异（p≥0.26）。进一步根据 AxL 对样本进行亚分类显示，在后皮质和 ACD 之间的负相关关系对于任何非白内障 AxL 组均不再具有统计学意义（p＞0.05）。在调整年龄后，整个样本以及所有 AxL 组中，白内障眼和非白内障眼中的 LT、前皮质、后皮质和核厚度没有显著差异（p≥0.43）。
白内障的存在并没有改变 LT、前皮质、后皮质和核与 ACD 之间的负相关关系。并且这种关系似乎并不重要 AxL。此外，白内障眼和非白内障眼中 LT、前皮质、后皮质和核之间的可能差异可能不是由晶状体混浊引起的，而可能是由于晶状体随年龄增长而发生的进行性生长所致。
