Meng Jiaqi, Wei Ling, He Wenwen, Qi Jiao, Lu Yi, Zhu Xiangjia
Eye Institute and Department of Ophthalmology, Eye & ENT Hospital, Fudan University, 83 Fenyang Road, Xuhui District, Shanghai, 200031, China.
Key Laboratory of Myopia, Ministry of Health, Shanghai, China.
Eye Vis (Lond). 2021 May 31;8(1):22. doi: 10.1186/s40662-021-00245-3.
To evaluate the distribution of lens thickness (LT) and its associations with other ocular biometric factors among cataract patients in Shanghai.
Twenty-four thousand thirteen eyes from 24,013 cataract patients were retrospectively included. Ocular biometric factors including LT, central corneal thickness (CCT), anterior chamber depth (ACD), white-to-white (WTW) distance, anterior corneal curvature, and axial length (AL) were obtained using the IOLMaster700. The associations between LT and general or ocular factors were assessed.
The mean age was 62.5 ± 13.6 years and 56.1% were female. The mean LT was 4.51 ± 0.46 mm. The LT was greater in older patients (P < 0.001). LT was positively correlated with CCT, while negatively correlated with ACD, WTW, and anterior corneal curvature (P < 0.001). Multivariate analysis revealed that increased LT was associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature (P < 0.001). LT changed with a variable behavior according to AL. In short eyes LT increased as AL increased, then decreased with longer AL in normal eyes and moderate myopic eyes, but increased again as AL increased in highly myopic eyes. Thickest LT was found in the 20.01-22 mm AL group. The correlation between LT and other biometric factors remained significant when stratified by ALs.
In a large Chinese cataractous population, we found that the thicker lens may be associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature. As AL increased, the change of LT was nonlinear, with the thickest lens seen in the 20-22 mm AL group.
评估上海白内障患者晶状体厚度（LT）的分布及其与其他眼部生物测量因素的关联。
回顾性纳入24013例白内障患者的24013只眼。使用IOLMaster700获取包括LT、中央角膜厚度（CCT）、前房深度（ACD）、白对白（WTW）距离、角膜前曲率和眼轴长度（AL）在内的眼部生物测量因素。评估LT与一般因素或眼部因素之间的关联。
平均年龄为62.5±13.6岁，女性占56.1%。平均LT为4.51±0.46mm。老年患者的LT更大（P<0.001）。LT与CCT呈正相关，而与ACD、WTW和角膜前曲率呈负相关（P<0.001）。多因素分析显示，LT增加与年龄较大、男性、CCT较厚、ACD较浅、WTW较大和角膜前曲率较平相关（P<0.001）。LT随AL的变化表现出不同的行为。在短眼中，LT随AL增加而增加，然后在正常眼和中度近视眼中随AL延长而降低，但在高度近视眼中随AL增加再次升高。在AL为20.01-22mm组中发现最厚的LT。按AL分层时，LT与其他生物测量因素之间的相关性仍然显著。
在一大群中国白内障患者中，我们发现较厚的晶状体可能与年龄较大、男性、CCT较厚、ACD较浅、WTW较大和角膜前曲率较平有关。随着AL增加，LT的变化是非线性的，在AL为20-22mm组中可见最厚的晶状体。
