Department of Scientific Computing, Informatics Center, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.
Institute of Science, Technology and Innovation, Federal University of Bahia, Camaçari, Bahia, Brazil.
PLoS One. 2023 Apr 28;18(4):e0285000. doi: 10.1371/journal.pone.0285000. eCollection 2023.
A mathematical model that simulates malaria transmission under the influence of transgenic mosquitoes refractory to malaria is presented in this paper. The zygosity of transgenic mosquitoes is taken into account and, consequently, the total population of mosquitoes is comprised of wild type and heterozygous and homozygous transgenic mosquitoes. These three mosquito varieties interact by mating and competition, and the genetic characteristics of their resulting offspring are in accordance with Mendelian genetics or the mutagenic chain reaction (MCR) technique. Although the incorporation of transgenic mosquitoes into the ecosystem reduces the incidence of malaria, the model also takes into account the importance of completing treatment in individuals with confirmed infection and the imminent risk of increased environmental temperature.
本文提出了一个数学模型，用于模拟转基因抗疟蚊子影响下的疟疾传播。该模型考虑了转基因蚊子的杂合性，因此蚊子的总数由野生型和杂合型及纯合型转基因蚊子组成。这三种蚊子通过交配和竞争相互作用，其后代的遗传特征符合孟德尔遗传学或诱变链反应（MCR）技术。虽然将转基因蚊子引入生态系统会降低疟疾的发病率，但该模型也考虑到了完成确诊感染个体治疗的重要性，以及环境温度升高的迫在眉睫的风险。
