Department of Internal Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Thoracic and Vascular Surgery Research Center, Shiraz University of Medical Science, Shiraz, Iran.
Sci Rep. 2023 Apr 28;13(1):6990. doi: 10.1038/s41598-023-34290-w.
The important association of erythropoietin (EPO) serum levels and chronic obstructive pulmonary disease (COPD) with anemia has been inadequately studied and remains a controversial issue. We aimed to shed light on this matter by comparing EPO levels in anemic and non-anemic COPD patients, along with a review of published literature. This cross-sectional study was conducted on COPD patients referred to the pulmonary clinic of Shahid Faghihi Hospital and Motahari clinic, Shiraz, Iran, for one year. We measured complete blood count, red blood cell indices, serum iron, TIBC and ferritin levels, serum EPO levels, and body mass index. Among 35 patients in this study, 28 males and 7 females were enrolled with a mean age of 54.57 ± 8.07 years. The average Forced expiratory volume in first second (FEV1) was 37.26 ± 7.33% and FEV1/FVC was 0.46 ± 0.12. Mean EPO levels were 30.29 ± 2.066 mU/mL. No statistically significant association was observed among erythropoietin levels and Hb, COPD severity, and age. There was no significant difference in EPO levels between anemic and non-anemic patients. EPO level, against the traditional expectation, didn't increase in COPD patients. EPO production also didn't compensate for the anemia of chronic disease which considers as a common comorbid disorder in these patients.
促红细胞生成素（EPO）血清水平与慢性阻塞性肺疾病（COPD）和贫血之间的重要关联尚未得到充分研究，仍然是一个有争议的问题。我们旨在通过比较贫血和非贫血 COPD 患者的 EPO 水平，并回顾已发表的文献来阐明这一问题。这项横断面研究在伊朗设拉子沙希德法希希医院和莫塔哈里诊所的肺科诊所对 COPD 患者进行了为期一年的研究。我们测量了全血细胞计数、红细胞指数、血清铁、总铁结合力和铁蛋白水平、血清 EPO 水平和体重指数。在这项研究的 35 名患者中，有 28 名男性和 7 名女性，平均年龄为 54.57±8.07 岁。平均第一秒用力呼气量（FEV1）为 37.26±7.33%，FEV1/FVC 为 0.46±0.12。平均 EPO 水平为 30.29±2.066 mU/mL。EPO 水平与 Hb、COPD 严重程度和年龄之间没有观察到统计学上的显著关联。贫血和非贫血患者的 EPO 水平没有差异。与传统预期相反，COPD 患者的 EPO 水平并没有增加。EPO 的产生也不能补偿这些患者常见的合并症——慢性病性贫血。
