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Brain histamine metabolism in transmissible spongiform encephalopathy (scrapie).

作者信息

Nowak J Z, Bogucki A, Liberski P

出版信息

J Neural Transm. 1986;65(3-4):187-92. doi: 10.1007/BF01249081.

DOI:10.1007/BF01249081
PMID:3711883
Abstract

The histamine (Hi) content and the activity of L-histidine decarboxylase (HD) in brains of scrapie infected hamsters were measured. No significant changes in Hi levels in particular brain areas were found when compared to controls. Decreased activity of HD was found in hypothalamus (p less than 0.02). Increased activity of the enzyme was observed in "rest of brain", which consisted mainly of thalamus and striatum (p less than 0.05).

摘要

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本文引用的文献

1
Depolarization-induced release of [(3)H]histamine by high potassium concentrations, electrical stimulation and veratrine from rat brain slices after incubation with the radiolabelled amine.用放射性标记的胺孵育大鼠脑片后，高钾浓度、电刺激和藜芦碱诱导的[(3)H]组胺去极化释放。
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单侧纹状体注射羊瘙痒病病原体后，阿扑吗啡诱导仓鼠出现的转圈行为。
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Properties and regional distribution of histidine decarboxylase in rat brain.大鼠脑中组氨酸脱羧酶的性质与区域分布
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