Department of Veterinary Medicine and Veterinary Medical Diagnostic Laboratory, College of Veterinary Medicine, University of Missouri, Columbia, Missouri, USA.
Department of Biomedical and Diagnostic Sciences, University of Tennessee, Knoxville, Tennessee, USA.
J Vet Intern Med. 2023 May-Jun;37(3):1250-1255. doi: 10.1111/jvim.16714. Epub 2023 Apr 28.
A 26-year-old mule gelding was evaluated for chronic weight loss and decreased appetite. The mule had been losing weight and intermittently hypophagic for approximately 7 months. Laboratory analysis of whole blood and plasma identified severe total hypercalcemia, marked hypophosphatemia, markedly increased parathyroid hormone concentration, and marked lymphocytosis. A sestimibi scan intended to identify parathyroid gland tissue was nondiagnostic. Results of flow cytometry and PCR for antigen receptor rearrangement (PARR) were consistent with a B cell lymphoproliferative disorder, likely chronic lymphocytic leukemia (CLL). Although not previously described concurrently, these conditions may sometimes arise together, complicating definition of the underlying mechanism for weight loss and hypercalcemia in aged equids.
一匹 26 岁的骡马被评估为慢性体重减轻和食欲不振。这匹骡马大约 7 个月来一直在减重，间歇性地食欲减退。全血和血浆的实验室分析发现严重的总高钙血症、显著的低磷血症、甲状旁腺激素浓度显著升高和显著的淋巴细胞增多。旨在识别甲状旁腺组织的 sestimibi 扫描无诊断意义。抗原受体重排（PARR）的流式细胞术和 PCR 结果符合 B 细胞淋巴增生性疾病，可能是慢性淋巴细胞白血病（CLL）。虽然以前没有同时描述过，但这些情况有时可能同时发生，使老年马属动物体重减轻和高钙血症的潜在机制的定义变得复杂。
