Kaya Ö, Kaya H
Department of Dermatology and Venerology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Department of Cardiology, Faculty of Medicine, Çanakkale Onsekiz Mart University, Çanakkale, Turkey.
Hippokratia. 2022 Jan-Mar;26(1):13-18.
The relationship between stasis dermatitis (SD), clinical factors, and heart failure (HF) outcomes in outpatients has not been previously assessed.
This observational cross-sectional study evaluated 324 patients admitted to the HF outpatient clinic. A total of 158 HF outpatients (100 males and 58 females) were enrolled in the study and were divided into two groups depending on whether they were diagnosed with SD within six months before attending the outpatient clinic. Forty-one patients (26 %) diagnosed with SD in the preceding six months were designated group 1, and 117 (74 %) not diagnosed were designated group 2.
Diabetes mellitus (DM) (OR =5.473, p <0.001), chronic obstructive pulmonary disease (COPD) (OR =2.623, p =0.039), and increased systolic pulmonary artery pressure (SPAP) (OR =1.061, p =0.001) values were independently associated with SD in multivariate logistic regression analysis. During the follow-up of 12 ± 4 months, no significant difference was documented between group 1 and group 2 regarding the death ratio (17 % vs. 19 %, p =0.991). In the multivariate Cox proportional-hazards model with a stepwise forward method, the presence of SD diagnosis [hazard ratio (HR) =2.933, 95 % Confidence Interval (CI): 1.660-5.181, p <0.001] and coronary artery disease (CAD) (HR=2.492, 95%CI: 1.238-5.018, p= 0.011) remained independently associated with the risk of HF-related hospitalization.
SD was found, for the first time, to be independently associated with DM, COPD, and increased SPAP values and determined as an independent predictor for HF-related hospitalization.HIPPOKRATIA 2022, 26 (1):13-18.
此前尚未评估门诊患者中淤积性皮炎（SD）、临床因素与心力衰竭（HF）结局之间的关系。
这项观察性横断面研究评估了324名入住HF门诊的患者。共有158名HF门诊患者（100名男性和58名女性）纳入研究，根据他们在就诊前六个月内是否被诊断为SD分为两组。在前六个月内被诊断为SD的41名患者（26%）被指定为第1组，未被诊断的117名患者（74%）被指定为第2组。
在多因素逻辑回归分析中，糖尿病（DM）（比值比[OR]=5.473，p<0.001）、慢性阻塞性肺疾病（COPD）（OR=2.623，p=0.039）和收缩期肺动脉压（SPAP）升高（OR=1.061，p=0.001）值与SD独立相关。在12±4个月的随访期间，第1组和第2组之间的死亡率无显著差异（17%对19%，p=0.991）。在采用逐步向前法的多因素Cox比例风险模型中，SD诊断的存在[风险比（HR）=2.933，95%置信区间（CI）：1.660 - 5.181，p<0.001]和冠状动脉疾病（CAD）（HR = 2.492，95%CI：1.238 - 5.018，p = 0.011）仍然与HF相关住院风险独立相关。
首次发现SD与DM、COPD和SPAP值升高独立相关，并被确定为HF相关住院的独立预测因素。《希波克拉底》2022年，26（1）：13 - 18。
