Schneider A P
JAMA. 1986 Jun 20;255(23):3270-4.
I have reviewed clinical trials that provide data relative to the comparative rates, means, or odds ratio of jaundiced normal breast-fed newborns vs jaundiced normal formula-fed newborns. A pooled analysis of 12 studies revealed moderate jaundice (serum bilirubin level, greater than or equal to 12 mg/dL) in 514 of 3,997 breast-fed vs 172 of 4,255 formula-fed newborns. An analysis of six of these 12 studies demonstrated severe jaundice (serum bilirubin level, greater than or equal to 15 mg/dL) in 54 of 2,655 breast-fed vs ten of 3,002 formula-fed newborns. Eleven of 13 studies found breast-fed newborns to have a higher mean serum bilirubin level. One study of 12,023 newborns found a significant (odds ratio, 1.80) relationship between breast-feeding and jaundice of the newborn. In conclusion, breast-feeding is one common cause of jaundice in normal newborns in the first week of life and beyond.
我回顾了一些临床试验，这些试验提供了关于正常母乳喂养新生儿与正常配方奶喂养新生儿黄疸的比较发生率、均值或比值比的数据。对12项研究的汇总分析显示，在3997名母乳喂养的新生儿中有514名出现中度黄疸（血清胆红素水平大于或等于12mg/dL），而在4255名配方奶喂养的新生儿中有172名出现中度黄疸。对这12项研究中的6项进行的分析表明，在2655名母乳喂养的新生儿中有54名出现重度黄疸（血清胆红素水平大于或等于15mg/dL），而在3002名配方奶喂养的新生儿中有10名出现重度黄疸。13项研究中有11项发现母乳喂养的新生儿平均血清胆红素水平较高。一项针对12023名新生儿的研究发现，母乳喂养与新生儿黄疸之间存在显著关联（比值比为1.80）。总之，母乳喂养是正常新生儿出生后第一周及以后黄疸的常见原因之一。
