Centro Andaluz de Biologia Molecular y Medicina Regenerativa (CABIMER), Consejo Superior de Investigaciones Cientificas (CSIC), Universidad de Sevilla, Universidad Pablo de Olavide, Seville, Spain.
MAP Laboratory, INSA Lyon, Claude Bernard University UMR5240, Villeurbanne, France.
Cell Cycle. 2023 May;22(10):1163-1168. doi: 10.1080/15384101.2023.2206350. Epub 2023 May 1.
Apart from a few rare exceptions, the maintenance of functional telomeres by recombination-based mechanisms is restricted to accidental and/or pathological situations. Originally described in the yeast S. cerevisiae, this mode of telomere repair has gained interest with the discovery of telomerase negative cancers that use alternative lengthening of telomeres (ALT cancer) dependent on homologous recombination. In both yeast and humans, it has been shown that recombination at telomeres is spatially regulated and occurs preferentially at the nuclear pore complexes (NPCs) in yeast and at ALT-associated promyelocytic leukemia nuclear bodies (APBs) in human cells. Here, we discuss the potential relationships between these two membrane-less structures and their role in enabling unconventional recombination pathways.
除了少数罕见的例外，基于重组的机制来维持功能端粒仅限于偶然和/或病理情况。这种端粒修复模式最初在酵母 S. cerevisiae 中被描述，随着端粒酶阴性癌症的发现，该模式引起了人们的兴趣，这些癌症依赖于同源重组的端粒的非经典延长（ALT 癌症）。在酵母和人类中，已经表明端粒处的重组受到空间调节，并且在酵母中优先发生在核孔复合物 (NPC) 处，在人类细胞中优先发生在 ALT 相关早幼粒细胞白血病核体 (APB) 处。在这里，我们讨论了这两种无膜结构之间的潜在关系及其在使非传统重组途径成为可能方面的作用。
