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Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX.

作者信息

de Nonneville Alexandre, Reddel Roger R

机构信息

Cancer Research Unit, Children's Medical Research Institute, Faculty of Medicine and Health, University of Sydney, Westmead, NSW, Australia.

Aix-Marseille Univ, CNRS, INSERM, Institut Paoli-Calmettes, CRCM, Marseille, France.

出版信息

Nat Commun. 2021 Mar 10;12(1):1552. doi: 10.1038/s41467-021-21794-0.

DOI:10.1038/s41467-021-21794-0
PMID:33692341
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7946928/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9383/7946928/922e89c31971/41467_2021_21794_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9383/7946928/254fc370bca9/41467_2021_21794_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9383/7946928/922e89c31971/41467_2021_21794_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9383/7946928/254fc370bca9/41467_2021_21794_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9383/7946928/922e89c31971/41467_2021_21794_Fig2_HTML.jpg

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Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX.端粒替代延长与ATRX/DAXX突变并非同义。
Nat Commun. 2021 Mar 10;12(1):1552. doi: 10.1038/s41467-021-21794-0.
2
Formal reply to "Alternative lengthening of telomeres is not synonymous with mutations in ATRX/DAXX".对“端粒的替代性延长并非等同于ATRX/DAXX突变”的正式回复
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Pan-cancer analysis of whole genomes.泛癌症全基因组分析。
Nature. 2020 Feb;578(7793):82-93. doi: 10.1038/s41586-020-1969-6. Epub 2020 Feb 5.
2
Genomic footprints of activated telomere maintenance mechanisms in cancer.癌症中端粒激活维持机制的基因组足迹。
Nat Commun. 2020 Feb 5;11(1):733. doi: 10.1038/s41467-019-13824-9.
3
Functional Loss of and Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells.在 LAPC4 前列腺癌细胞中， 和 的功能丧失会激活端粒的替代性延长（ALT）。
升高的活性氧可驱动ATRX缺失型癌症中的端粒替代延长途径。
Nucleic Acids Res. 2025 Feb 8;53(4). doi: 10.1093/nar/gkaf061.
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Prevalence of alternative lengthening of telomeres in pediatric sarcomas determined by the telomeric DNA C-circle assay.通过端粒DNA C环分析确定的小儿肉瘤中端粒替代延长的发生率。
Front Oncol. 2024 Aug 19;14:1399442. doi: 10.3389/fonc.2024.1399442. eCollection 2024.
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Targeting ATR in patients with cancer.针对癌症患者的 ATR 靶点治疗。
Nat Rev Clin Oncol. 2024 Apr;21(4):278-293. doi: 10.1038/s41571-024-00863-5. Epub 2024 Feb 20.
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A pan-sarcoma landscape of telomeric content shows that alterations in RAD51B and GID4 are associated with higher telomeric content.端粒含量的泛肉瘤图谱显示，RAD51B和GID4的改变与更高的端粒含量相关。
NPJ Genom Med. 2023 Sep 14;8(1):26. doi: 10.1038/s41525-023-00369-6.
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