Department of Chemistry, SRM Institute of Science and Technology, SRM Nagar, Potheri, Kattankulathur, Tamil Nadu-603203, India.
Department of Chemistry, Raghunathpur College, Sidho-Kanho-Birsha University, Purulia, West Bengal-723133, India.
Org Biomol Chem. 2023 May 17;21(19):3942-3983. doi: 10.1039/d3ob00209h.
Adenosine triphosphate (ATP), one of the biological anions, plays a crucial role in several biological processes including energy transduction, cellular respiration, enzyme catalysis and signaling. ATP is a bioactive phosphate molecule, recognized as an important extracellular signaling agent. Apart from serving as a universal energy currency for various cellular events, ATP is also considered a factor responsible for numerous physiological activities. It regulates cellular metabolism by breaking phosphoanhydride bonds. Several diseases have been reported widely based on the levels and behavior of ATP. The variation of ATP concentration usually causes a foreseeable impact on mitochondrial physiological function. Mitochondrial dysfunction is responsible for the occurrence of many severe diseases such as angiocardiopathy, malignant tumors and Parkinson's disease. Therefore, there is high demand for developing a sensitive, fast-responsive, nontoxic and versatile detection platform for the detection of ATP. To this end, considerable efforts have been employed by several research groups throughout the world to develop specific and sensitive detection platforms to recognize ATP. Although a repertoire of optical chemosensors (both colorimetric and fluorescent) for ATP has been developed, many of them are not arrayed appropriately. Therefore, in this present review, we focused on the design and sensing strategy of some chemosensors including metal-free, metal-based, sequential sensors, aptamer-based sensors, nanoparticle-based sensors . for ATP recognition diverse binding mechanisms.
三磷酸腺苷（ATP）是一种生物阴离子，在包括能量转导、细胞呼吸、酶催化和信号转导在内的多种生物学过程中发挥着关键作用。ATP 是一种具有生物活性的磷酸分子，被认为是一种重要的细胞外信号传递剂。除了作为各种细胞事件的通用能量货币外，ATP 还被认为是许多生理活动的一个因素。它通过打破磷酸酐键来调节细胞代谢。据报道，许多疾病的发生都与 ATP 的水平和行为有关。ATP 浓度的变化通常会对线粒体生理功能产生可预见的影响。线粒体功能障碍是心血管疾病、恶性肿瘤和帕金森病等许多严重疾病发生的原因。因此，人们对开发用于检测 ATP 的灵敏、快速响应、无毒和多功能的检测平台有很高的需求。为此，世界各地的许多研究小组都在努力开发用于识别 ATP 的特定和灵敏的检测平台。尽管已经开发了许多用于 ATP 的光学化学传感器（比色和荧光），但其中许多传感器的排列并不合适。因此，在本综述中，我们重点介绍了一些化学传感器的设计和传感策略，包括无金属、基于金属、顺序传感器、基于适配体的传感器、基于纳米粒子的传感器，用于 ATP 的识别，涉及到多种结合机制。
