Department of Medical Biochemistry, University of Ghana Medical School, Korle-Bu, Ghana.
Department of Surgery, University of Ghana Medical School, Korle-Bu, Ghana.
Cancer Control. 2023 Jan-Dec;30:10732748231155702. doi: 10.1177/10732748231155702.
Malignancies affecting the gastrointestinal tract are among the principal threats to global public health. In Ghana, these cancers are responsible for a significant number of hospitalizations and mortalities at major health facilities across the country. The increasing incidence of these malignancies necessitates an investigation of the association between lifestyle (modifiable risk factors) and these disorders.
To determine the association between lifestyle and gastrointestinal cancers of patients attending the Korle Bu Teaching Hospital (KBTH).
This was a cross-sectional prospective study where demographic data were obtained from consenting patients diagnosed with gastrointestinal cancer at the oncology and surgical clinics of the KBTH. Diagnostic investigations, gastrointestinal cancer phenotype, year of diagnosis and treatment(s) received were also obtained from the participants. Information on smoking status, alcohol consumption, sources of dietary proteins, daily intake of water, and frequency of fruit intake were also obtained from the participants. Odds ratio and -values were determined to ascertain whether there might be a significant association between gastrointestinal cancers and specified lifestyle.
Colorectal cancers were the most prevalent form of gastrointestinal cancers among the participants. Alcohol consumption or smoking habits were not significantly associated with onset of gastrointestinal cancers among the study participants. There was a significant association but weak correlation between red meat consumption and the colorectal cancer.
This study shows consumption of red meat to be a modifiable risk factor that is associated with lower gastrointestinal cancers in the study participants. Further longitudinal studies using large number of participants is needed for confirming the observations from this current study.
影响胃肠道的恶性肿瘤是全球公共卫生的主要威胁之一。在加纳，这些癌症是导致全国主要医疗机构大量住院和死亡的主要原因。这些恶性肿瘤的发病率不断上升，需要调查生活方式（可改变的危险因素）与这些疾病之间的关系。
确定在科托布教学医院（KBTH）就诊的患者的生活方式与胃肠道癌症之间的关联。
这是一项横断面前瞻性研究，从在 KBTH 的肿瘤学和外科诊所被诊断为胃肠道癌症的同意参与的患者中获得人口统计学数据。还从参与者中获得了诊断性检查、胃肠道癌症表型、诊断年份和接受的治疗。还从参与者那里获得了关于吸烟状况、饮酒、饮食蛋白质来源、每日水摄入量和水果摄入量的信息。确定了优势比和-值，以确定胃肠道癌症与特定生活方式之间是否可能存在显著关联。
结直肠癌是参与者中最常见的胃肠道癌症形式。在研究参与者中，饮酒或吸烟习惯与胃肠道癌症的发病没有显著关联。在红肉消费与结直肠癌之间存在显著关联，但相关性较弱。
这项研究表明，食用红肉是一种可改变的危险因素，与研究参与者的较低的胃肠道癌症有关。需要使用大量参与者进行进一步的纵向研究来证实本研究的观察结果。
