Lee Sunmyoung, Ono Tamiko, Masaaki Shiota, Fujita Akihiro, Matsubara Masaaki, Zappa Achille, Yamada Issaku, Aoki-Kinoshita Kiyoko F
Glycan and Life Systems Integration Center (GaLSIC), Soka University, Hachioji, Tokyo, Japan.
Institute for Glyco-Core Research, Nagoya University, Nagoya, Japan.
Anal Bioanal Chem. 2025 Feb;417(5):907-919. doi: 10.1007/s00216-024-05692-0. Epub 2024 Dec 17.
Glycosylation, characterized by its complexity and diversity, is a common system across all domains of life. The glycosylation of proteins or lipids imparts them with structural and functional roles, ranging from development to infectious or Mendelian disease. The high-throughput-based omics data has revealed that glycans are involved in important cellular processes. Comprehensive knowledge of glycosylation has contributed not only to the fundamental concepts in glycoscience but also to its applications, including the development of molecular markers for diagnosis and therapeutic tools for treating diseases. The GlyCosmos Glycoscience Portal (GlyCosmos) has undergone significant updates to better support the scientific community in studying glycosylation-related phenomena. Key enhancements include the integration of expanded datasets linking glycans to other omics fields, improved tools for glycan structure prediction and analysis, and upgraded visualization capabilities to streamline data interpretation. A strengthened focus on data standardization has also been introduced, fostering interoperability between glycoscience resources and external databases. Since its release in 2019, the portal has seen a fivefold increase in user engagement, reflecting its growing relevance. These recent advancements aim to provide researchers with a more comprehensive and user-friendly platform, enabling deeper insights into glycan roles in cellular processes and disease mechanisms. GlyCosmos will continue to evolve, prioritizing community needs and advancing the integration of glycoscience with broader biological and biomedical research.
糖基化以其复杂性和多样性为特征，是一种存在于所有生命领域的常见系统。蛋白质或脂质的糖基化赋予它们结构和功能作用，涵盖从发育到感染性疾病或孟德尔疾病等多个方面。基于高通量的组学数据表明，聚糖参与重要的细胞过程。对糖基化的全面了解不仅有助于糖科学的基本概念，也有助于其应用，包括开发用于诊断的分子标志物和治疗疾病的工具。糖基化宇宙糖科学门户（GlyCosmos）已进行了重大更新，以更好地支持科学界研究与糖基化相关的现象。关键改进包括整合将聚糖与其他组学领域联系起来的扩展数据集、改进聚糖结构预测和分析工具，以及提升可视化能力以简化数据解读。还加强了对数据标准化的关注，促进糖科学资源与外部数据库之间的互操作性。自2019年发布以来，该门户的用户参与度增长了五倍，反映出其日益增长的相关性。这些最新进展旨在为研究人员提供一个更全面、用户友好的平台，使他们能够更深入地了解聚糖在细胞过程和疾病机制中的作用。GlyCosmos将继续发展，优先考虑社区需求，并推动糖科学与更广泛的生物学和生物医学研究的整合。
