节能器：单核细胞在饥饿时在骨髓中休眠。

Energy saver: Monocytes hibernate in bone marrow upon fasting.

机构信息

Institute of Comparative Molecular Endocrinology, Ulm University, Ulm, Germany.

Department of Pediatrics and Adolescent Medicine, Ulm University Medical Center, Ulm, Germany.

出版信息

Cell Metab. 2023 May 2;35(5):734-736. doi: 10.1016/j.cmet.2023.04.008.

DOI:10.1016/j.cmet.2023.04.008

PMID:37137288

Abstract

Immune functions are influenced by the nutritional state. In a recent publication in Immunity, Janssen et al. unveil that a fasting-induced glucocorticoid release makes monocytes move from blood into the bone marrow. Upon refeeding, these chronologically older monocytes are again released and exert detrimental effects during bacterial infection.

摘要

免疫功能受营养状态的影响。在最近发表于《Immunity》的一篇论文中，Janssen 等人揭示了禁食诱导的糖皮质激素释放使单核细胞从血液迁移到骨髓。重新进食后，这些在时间上更老的单核细胞再次被释放出来，并在细菌感染期间产生有害影响。