Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL; Mayo Clinic Center for Women's Health, Mayo Clinic, Rochester, MN.
Division of General Internal Medicine, Mayo Clinic, Jacksonville, FL; Mayo Clinic Center for Women's Health, Mayo Clinic, Rochester, MN.
Mayo Clin Proc. 2023 May;98(5):701-712. doi: 10.1016/j.mayocp.2023.01.010.
To further examine a potential link between migraine and vasomotor symptoms as well as hypertension as a cardiovascular disease risk factor, potentially explaining the association in midlife women.
We conducted a cross-sectional analysis from the Data Registry on Experiences of Aging, Menopause, and Sexuality using questionnaire data from women aged 45 to 60 years seen in women's clinics at a tertiary care center from May 15, 2015, through January 31, 2022. A history of migraine was self-reported; menopause symptoms were assessed with the Menopause Rating Scale. Associations between migraine and vasomotor symptoms were evaluated utilizing multivariable logistic regression models adjusting for multiple factors.
Of 5708 women included in the analysis, 1354 (23.7%) reported a migraine history. The total cohort had a mean age of 52.8 years, most (5184 [90.8%]) were White, and 3348 (58.7%) were postmenopausal. In adjusted analysis, women with migraine were significantly more likely to have severe/very severe hot flashes vs no hot flashes compared with women without migraine (odds ratio, 1.34; 95% CI, 1.08 to 1.66; P=.007). Migraine was associated with a diagnosis of hypertension in adjusted analysis (odds ratio, 1.31; 95% CI, 1.11 to 1.55; P=.002).
This large cross-sectional study confirms an association between migraine and vasomotor symptoms. Migraine also was associated with hypertension, potentially providing a link with cardiovascular disease risk. Given the high prevalence of migraine in women, this association may help identify those at risk for more severe menopause symptoms.
进一步研究偏头痛与血管舒缩症状之间的潜在联系，以及高血压作为心血管疾病的风险因素，这可能可以解释中年女性偏头痛的发病机制。
我们对使用来自于 2015 年 5 月 15 日至 2022 年 1 月 31 日期间在一家三级保健中心的女性诊所就诊的年龄在 45 至 60 岁之间的女性的问卷调查数据，进行了来自于体验衰老、绝经和性行为数据登记的横断面分析。偏头痛病史由自我报告；绝经症状采用绝经评定量表进行评估。利用多变量逻辑回归模型，调整了多种因素，评估了偏头痛与血管舒缩症状之间的关联。
在纳入分析的 5708 名女性中，有 1354 名（23.7%）报告有偏头痛病史。总队列的平均年龄为 52.8 岁，大多数（5184 [90.8%]）为白人，3348 名（58.7%）为绝经后。在调整分析中，与无偏头痛的女性相比，有偏头痛的女性出现严重/非常严重潮热的可能性显著更高（比值比，1.34；95%置信区间，1.08 至 1.66；P=.007）。在调整分析中，偏头痛与高血压的诊断相关（比值比，1.31；95%置信区间，1.11 至 1.55；P=.002）。
这项大型横断面研究证实了偏头痛与血管舒缩症状之间的关联。偏头痛也与高血压有关，这可能为与心血管疾病风险的关联提供了依据。鉴于女性偏头痛的高患病率，这种关联可能有助于识别那些有更严重绝经症状风险的人群。
